Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J Immunol. 2008; 181 :6170–6177.Lunemann A, Lunemann JD, Roberts S, et al. Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition . J Immunol ...
In summary, resting microglia primarily express the Gαs-coupled β2 receptors, whereas activated microglia primarily express the Gαi-coupled α2A receptors. To determine whether the low levels of α1 receptor mRNA detected by quantitative PCR lead to expression of functional receptors, we ...
Accumulation of intracellular and extracellular misfolded mSOD1 may be key events regulating the transformation from neuroprotective alternatively activated M2 microglia to cytotoxic classically activated M1 microglia. Intracellular and extracellular mSOD1 utilizing different pathways may enhance the production and...
Microglia Binding of acetylcholine to receptors on the postganglionic neuron causes by opening channels that primarily permit sodium to enter the cell. a. muscarinic; a depolarization b. muscarinic; a hyperpolarization c. nicotinic; a depolarization d. nicot...
initial M1/M2 polarization processes; for example, M2-polarized macrophages can convert to the M1-activated status under certain conditions and vice versa. The classically activated M1 macrophages comprise immune effector cells with an acute inflammatory phenotype. These are highly aggressive against ...
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Double-labeling EAE sections for NG2 and F4/80 or CD45 failed to reveal cells that co-expressed both antigens, suggesting that reactive NG2+ cells are distinct from activated microglia. However, a close spatial relationship between NG2+ cells and microglia was observed in the normal brain ...
Resting and activated human microglia ex vivo: relation with cytokine productionresting and activated human microglia ex vivo: relation with cytokine production.doi:10.1016/0165-5728(96)80946-5B. BecherL. LafortuneI.P. AntelJournal of Neuroimmunology...
Glial cells and more specifically microglia become reactive in the presence of A. In a triple transgenic model of AD (3 脳 Tg-AD), we found a significant increase in activated microglia at 12 (by 111%) and 18 (by 88%) months of age when compared with non-transgenic (non-Tg) ...
Neurochemical ResearchH. Chen, C. Wang, X. Wei, X. Ding, W. Ying, Malate-aspartate shuttle inhibitor aminooxyacetate acid induces apoptosis and impairs energy metabolism of both resting microglia and LPS-activated microglia, Neurochem. Res. 40 (2015) 1311-1318....