2001. Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler's murine encephalomy- elitis virus infection leading to demyelination. J Neuroimmunol 118:256-267.L. Zheng, M.A. Calenoff, M.C. Dal Canto, Astrocytes, not microglia, are the main cells ...
Amyotrophic lateral sclerosis--are microglia killing motor neurons? Progression of amyotrophic lateral sclerosis may be influenced by microglia, immune cells of the central nervous system. DR Borchelt - 《New England Journal of Medicine》 被引量: 0发表: 2006年 Skeletal muscle-restricted expression of...
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been publish...
Background Microglia are the primary immune cells of the brain whose phenotype largely depends on their surrounding micro-environment. Microglia respond to... AM Smith,HM Gibbons,RL Oldfield,... - 《Journal of Neuroinflammation》 被引量: 51发表: 2013年 The colony-stimulating factor 1 (CSF-1)...
Behavioral changes in the irradiated males corresponded to physical alterations in their brains. Most notably, microglia – resident immune cells of the brain and spinal cord – became very active following radiation. The boosted activity was measured in the hippocampus, a brain structure integral to...
microglia, thus safeguarding the neurovasculature. Furthermore, alisol A promoted the survival of neurons by reducing the proportion of Bax/Bcl-2, and safeguarded mind microvascular endothelial cells (BMECs) by upregulating the expression of ZO-1, Occludin and CD31. The phosphorylation of necessary...
High levels of leucine-rich repeat kinase 2 (LRRK2) in immune cells disrupt immune system function in patients with Parkinson's disease (PD). Mutations in LRRK2 are the most common genetic cause of PD. Although LRRK2 is found in many immune cells, research efforts have focussed on ...
Patients with PD have elevated proinflammatory cytokines (i.e., interleukin 1-beta, interleukin-6, interferon gamma, and tumor necrosis factor-alpha) in their cerebrospinal fluid (CSF) and plasma, all produced by microglia and immune cells [34,35,36,37]. These pathological hallmarks of PD, ...
97.9 ± 0.6% of spinal cord microglia (Fig.2a–dand Supplementary Figure5). In contrast, PLX73086 did not affect the microglial population. To examine the effects of the two CSF1R inhibitors on peripheral immune cells, we next performed a cytometric analysis of leukocyte subsets in the...
Each barrier also contains a different array of immune cells that survey the physical barrier and provide innate and adaptive immunity. Here, we compare and contrast the different properties of the gut immune barrier and the blood-brain barrier as well as the mechanisms that specific pathogens ...