Non-coding exons of ε-globin mRNA originating within the 236 kb upstream region of the ε-globin gene were identified in human primary tissues and K562 cells. One predominant type of upstream ε mRNA, which or
CompositionComposed of exons (coding sequences) and introns (DNA regions with no known function)Composed of regulatory elements, repeating sequences, pseudogenes, introns, and telomeres SynthesisUndergoes transcription to synthesize mRNAsUndergoes transcription to synthesize regulatory RNAs inc...
we reconstructed the mapped reads using Stringtie [40]; (2) aligned the spliced transcripts and the reference transcripts using cuff compare; (3) screened transcripts longer than 200 bp containing two or more exons from the alignment; (4) finally we chose the transcripts with non-coding ability...
Filled and open boxes denote coding and noncoding exons of Xcr1, respectively. b, Southern blot analysis of Xcr1+/+ and Xcr1Cre/+. Genomic DNAs were isolated from mice tails, digested with SalI, electrophoresed, and hybridized with the 5′-radiolabelled probe indicated in a. Southern ...
lyrata gene annotation97, where the gene includes 5’ untranslated regions (UTRs), start codons, exons, introns, stop codons, and 3’ UTRs. Then we refined this inclusive list and identified parallel differentiation candidates as genes identified as candidates in at least two population pairs. ...
All OSK genes house 11 exons and 10 introns and the positions of introns within the coding regions are fully conserved in all these genes. Histochemical analyses using OSK promoter: β-glucronidase ( OSKP:GUS) reporter genes showed that expression patterns of OSK1P:GUS and OSK24P:GUS were ...
LINE1以非经典转录本变体形式剪切来调控T细胞静止和耗竭状态《Nature Genetics》意大利米兰大学,IF: 41.307,中科院一区 Cite:Marasca, F., Sinha, S., Vadalà, R. et al.LINE1 are spliced in non-canonical t…
We began with genes having at least two RefSeq mRNAs and obtained 36,643 internal coding exons from 3,362 genes (including 252 NMD candidates and 3,110 non-NMD genes) (Table 3). Among these, we identified 278 NMD-specific exons and 2,353 NMD-nonspecific exons. Since NMD-specific exons ...
The TGF-β/Smad pathway and coregulators Ski and SnoN clearly regulate each other through several positive and negative feedback mechanisms. Thus, these cross-regulatory processes finely modify the TGF-β signaling outcome as they control the magnitude and duration of the TGF-β signals. As a ...