Lao et al., "Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells," Journal of Leukocyte Biology, vol. 101, no. 4, pp. 901-911, 2017.Rudloff I, Cho SX, Lao JC, et al. Monocytes and dendritic cells are the primary sources of interleukin 37 ...
Thus, monocytes exposed to the appropriate conditions become powerful activators of tumor-specific CD8+T cells and antitumor immunity. 展开 关键词: dendritic cells T cells monocyte-derived dendritic cells CSF1R tumor immunotherapy mouse models
To perform their cellular function, T cells need to be activated by antigen-presenting cells, such as dendritic cells (DCs). The aim of this work was to analyze DC differentiation and activation from monocytes of HTLV-1-infected individuals. We demonstrated that monocytes from HTLV-1-infected ...
In teleosts, as in mammals, the main types of professional antigen-presenting cells (APCs) are dendritic cells (DCs), monocytes/macrophages, and B cells. In the current study, flow cytometry, immunostaining and qPCR have been used to show that neutrophils in the teleost fish Atlantic salmon (...
Blood monocytes exist in two primary subpopulations, characterized as classical inflammatory or non- classical. While classical monocytes extravasate into inflamed tissue and give rise to macrophages or dendritic cells, the recruitment kinetics and functional role of non-classical monocytes remains ...
Dendritic cells (DC) generated after a short-term exposure of monocytes to IFN-alpha and GM-CSF (IFN-DC) are highly effective in inducing cross-priming of CD8(+ )T cells against viral antigens. We have investigated the mechanisms responsible for the special attitude of these DC and compared...
The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan and is expressed, among other cell types, in immune cells such as dendritic cells (DCs), monocytes, and macrophages. It has been shown that the activity of IDO has a broad regulatory function in the ...
The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan and is expressed, among other cell types, in immune cells such as dendritic cells (DCs), monocytes, and macrophages. It has been shown that the activity of IDO has a broad regulatory function in the im...
cells and is necessary for uptake and transfer to CD4 T cells11,32,33,34,44,45,46,51. Furthermore we have shown blocking the ability of HIV to bind both DC-SIGN and mannose receptor on MDDCs derived in vitro from blood CD14+monocytes significantly blocks HIV uptake11,12. However, we...
The capacity of dendritic cells (DC) to initiate immune responses is dependent on their specialized migratory and tissue homing properties. Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte-macrophage col...