ImmunogenSynthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Androgen Receptor (AR-V7 specific) aa 600 to the Cterminus. Sequence- Gene ID367 SwissProtC0JKD3 SynonymsAIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; AR ...
A novel ENZ-resistant circRNA, circSRCAP, was identified and shown to be upregulated in ENZ-resistant C4-2B (ENZR-C4-2B) cells, correlating with increased AR-V7 protein levels. circSRCAP is generated via splicing by eIF4A3, forming a loop structure and is exported from the nucleus by the...
Next, we wondered how nobiletin downregulates AR-V7, such as by inhibiting AR-V7 protein synthesis or promoting its degradation. On one hand, real-time quantitative PCR assay was performed to detect the changes of AR-V7 mRNA in 22Rv1 cells treated with various concentrations of nobiletin, but...
Different alternative combinations of exons and splice sites generated during splicing can produce multiple transcripts and different protein sequences from a single locus. This is, in part, responsible for the much greater diversity of the transcriptome and proteome than would be obtained from a ...
One of the most common variants, AR variant 7 (ARv7), arises through cryptic exon inclusion. This AR isoform consists of a conserved N-terminal activation function-1 (AF-1) domain, a central DNA-binding domain, a partial hinge region and a unique C-terminal 16-amino-acid sequence, in ...
Using a Bimolecular Fluorescence Complementation (BiFC) assay, we have mapped the AR interaction region to a 21-amino acid sequence found in the N-terminus and designed a peptide, AT1, based on this sequence.Peptide AT1 reduced the interaction of TM4SF3 with either AR or AR-V7 and caused ...
Pre-Training Protein Encoder via Siamese Sequence-Structure Diffusion Trajectory Prediction[ArXiv] Zuobai Zhang*,Minghao Xu*,Aurelie Lozano,Vijil Chenthamarakshan,Payel Das,Jian Tang Overview Siamese Diffusion Trajectory Prediction (SiamDiff)is a diffusion-based pre-training algorithm for protein structure...
Two inhibitors, geldanamycin and MJC13 (which block HSP90 and its cochaperone FKBP52, respectively), were demonstrated to be effective at blocking ligand-dependent AR activity but were unable to modulate ARv7 protein stability or transcriptional activity [81], suggesting that ARVs may contribute ...
蛋白别名:Androgen receptor-interacting protein 4; AR interacting protein 4; Helicase ARIP4; RAD54-like protein 2 基因别名:ARIP4; HSPC325; KIAA0809; RAD54L2; SRISNF2L UniProt ID:(Human) Q9Y4B4 Entrez Gene ID:(Human) 23132 功能 DNA bindinghelicase activityprotein bindingATP binding ...
In addition, AR-V7 protein expression was predominantly localized to the nucleus in tumor cells from patients with mCRPC. In some cases, different metastases from the same patient were heterogeneous with regard to AR-V7 expression. Finally, AR-V7–negative patients showed significantly better ...