protein sequence的意思是蛋白质序列或蛋白序列。以下是关于蛋白质序列的详细解释：定义：蛋白质序列是指构成蛋白质的氨基酸按照一定顺序连接而成的线性排列。这种排列顺序决定了蛋白质的三维结构和功能。重要性：蛋白质序列是蛋白质功能的基础。不同的氨基酸序列会导致蛋白质具有不同的空间构象和生物活性，从而...
The database provides access to over 214 million predicted structures, although some sequences might be outdated compared to UniProt due to less frequent data releases in the AlphaFold DB. Predictions of UniProt sequences are outputs of a single model run. In contrast, Swiss-Prot/proteomes entrie...
compared to site-independent sequence variation models which do not account for covariation11,12. They are “generative” in the sense that they define the probability,p(S), that a protein sequenceSresults from the evolutionary process. Intriguingly, the probability distributionp(S) can be used t...
Our approach enables the computational design of protein crystals with high accuracy, and the designed protein crystals, which have both structural and assembly information encoded in their primary sequences, provide a powerful platform for biological materials engineering. This is a preview of ...
Keywords: Diffusion model, Deep generative model, Protein generation, Framework, Sequence design The study explores the application of evolutionary diffusion models in protein generation, emphasizing sequence design. [Paper]A high-level programming language for generative protein design Brian Hie, Salvatore...
Andre, "Using programmatic motifs and genetic programming to classify protein sequences as to extracellular and membrane cellular location," in Evolu- tionary Programming VII: Proceedings of the 7th Annual Con- ference on Evolutionary Programming, V. W. Porto, N. Sara- vanan, D. Waagen, and A...
Note that this method is not suitable for identifying the highly similar local regions between the two sequences. Local alignment, on the other hand, does not assume that the two sequences in question are similar over their entire length. In fact, it only determines regions with the highest ...
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenges. Here, we d
Protein Pairwise Sequence Alignment The alignment tools are similar to the DNA alignment tools BLASTP, FASTA Main difference: instead of scoring match (+2) and mismatch (-1) we have similarity scores: Score s(i,j) > 0 if amino acids i and j have similar properties Score s(i,j) is ...
Conditional random fields (CRFs): Markovian models devise to sequence labelling tasks. As for Hidden Markov Models, training and inference are based on dynamic programming algorithms [7]. A variant called Grammatical-Restrained Hidden Random Fields (GRHCRF) allows constraining the labelling according ...