近日,知名药学综合学术期刊Acta Pharmaceutica Sinica B (IF:14.903) 发表了我院吴红茜副研究员合作发表的关于新型AR抑制剂治疗耐药性前列腺癌的最新研究论文“A novel inhibitor of ARfl and ARv7 induces protein degradation to over...
Nuclear- specific AR-V7 protein localization is necessary to guide treatment selection in metastatic castration-resistant prostate cancer. Eur Urol. 2017;71(6):874-82.Scher HI, Graf RP, Schreiber NA, et al. Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in...
AR-V7 Reference Standard询价产品描述 产品数据库Introduction Catalog ID CBP20225R Format RNA Description AR-V7 is the only protein variant that can be detected in clinical samples. AR-V7 contains only the first three of the eight exons in the full-length (FL) form, followed by a ...
因此靶向ARfl/ARv7治疗ENZ耐药性晚期前列腺癌药物是下一代AR拮抗剂的研发重点。 中国药科大学药学院吴红茜副研究员所在团队在《药学学报》英文刊(Acta Pharmaceutica Sinica B)2022年11期合作发表了题为“A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in adva...
Next, we wondered how nobiletin downregulates AR-V7, such as by inhibiting AR-V7 protein synthesis or promoting its degradation. On one hand, real-time quantitative PCR assay was performed to detect the changes of AR-V7 mRNA in 22Rv1 cells treated with various concentrations of nobiletin, but...
We found that protein expression of AR-V7 was more fre- quently detected in CRPC compared with hormone-sensitive PCa (p , 0.001), and the expression of AR-V7 in newly diagnosed meta- static PCa was correlated with shorter time to CRPC, with median time to CRPC for patients with and ...
Expression of the ARv7-repressed targets and ARv7 protein expression are negatively correlated and predicts for outcome in PCa patients. Our results provide insights into the role of ARv7 in CRPC and define a set of potential biomarkers for tumors dependent on ARv7. Graphical Abstract Download:...
The AR-V7 protein was localized to the cytoplasm in hormone-naive tumor cells and partially localized to the nucleus in CRPC tumor cells. Recently, Sharp et al39 assessed AR-V7 expression using immunohistochemistry (IHC) in 358 primary prostate tumor specimens and 293 metastatic biopsy specimens ...
题目:A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer 译名:一种新的ARF1和ARv7抑制剂诱导蛋白质降解以克服晚期前列腺癌对苯扎鲁胺的耐药性 期刊:Acta Pharmaceutica Sinica B ...
the AR-V7 protein that results as a consequence of the AR-V7 splicing variant contains the first 3 exons but is missing exons 4, 5, 6, 7, and 8. Those exons that are missing are the parts that encode the ligand-binding domain, the part where androgens bind to and also the part of...