AR-V7 Reference Standard询价产品描述 产品数据库Introduction Catalog ID CBP20225R Format RNA Description AR-V7 is the only protein variant that can be detected in clinical samples. AR-V7 contains only the first three of the eight exons in the full-length (FL) form, followed by a ...
近日,知名药学综合学术期刊Acta Pharmaceutica Sinica B (IF:14.903) 发表了我院吴红茜副研究员合作发表的关于新型AR抑制剂治疗耐药性前列腺癌的最新研究论文“A novel inhibitor of ARfl and ARv7 induces protein degradation to over...
Remarkably, AR-V7 was an independent negative prognostic factor in high-risk prostate cancer patients of cohort I who were selected to receive adjuvant treatment. CONCLUSIONS: Prostate cancer cells with high nuclear AR-V7 protein expression can be detected in a substantial proportion of tumors at ...
AR-V7: 一种AR 降解剂药物,由Yale University (Yale University)公司最早进行研发,目前全球最高研发状态为无进展,作用机制: AR 降解剂(雄激素受体 降解剂),治疗领域: 肿瘤,泌尿生殖系统疾病。
Mechanistically, AKR1C3 interacts with AR-V7 protein in CRPC cells, which can reciprocally inhibit AR-V7 and AKR1C3 protein degradation. Biologically, this complex is essential for in vitro and in vivo tumour growth of CRPC cells after androgen deprivation as it represses B4GALT1, a unique ...
So, the AR-V7 protein that results as a consequence of the AR-V7 splicing variant contains the first 3 exons but is missing exons 4, 5, 6, 7, and 8. Those exons that are missing are the parts that encode the ligand-binding domain, the part where androgens bind to and also the ...
Next, we wondered how nobiletin downregulates AR-V7, such as by inhibiting AR-V7 protein synthesis or promoting its degradation. On one hand, real-time quantitative PCR assay was performed to detect the changes of AR-V7 mRNA in 22Rv1 cells treated with various concentrations of nobiletin, but...
Androgen Receptor (AR-V7 Specific) (E3O8L) Rabbit mAb recognizes endogenous levels of total AR-V7 protein. This antibody does not cross-react with full-length AR protein, but immunoprecipitates a 120 kDa protein of unknown identity. Species Reactivity: Human Source / Purification ...
We show in ARv7-dependent CRPC models that ARv7 binds together with ARfl to repress transcription of a set of growth-suppressive genes. Expression of the ARv7-repressed targets and ARv7 protein expression are negatively correlated and predicts for outcome in PCa patients. Our results provide ...
PROTAC AR-V7 degrader-2 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels.PROTAC AR-V7 degrader-2 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining. In Vivo: PROTAC AR-V7 degrader-2 (compound 16; 2.5 mg/mL; intratumor injection) ...