Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages 凋亡细胞身份诱导巨噬细胞对 IL-4 产生不同的功能应答 (导读 才生)巨噬细胞是功能异质性细胞,对凋亡细胞的清楚至关重要。本研究发现在白细胞介素-4(IL-4)富集的...
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells TRAIL, but not FasL, effectively induced apoptotic cell death in most of 5 chronic myelogenous leukemia–derived and 7 acute leukemia–derived Ph1-positive... K Uno,T Inukai,N...
Nitric oxide synthase induces macrophage death by apoptosis. Stimulation processes effective for macrophage (MΦ) cytostasis induction also led to a L-arginine-dependent MΦ cell death by apoptosis in parallel to nit... M Sarih,V Souvannavong,A Adam - 《Biochemical & Biophysical Research Communi...
the interaction between nesprin-2G and Bax. Duolink PLA assay was preformed using the Bax (6A7) Ab and anti-nesprin-2G Ab. The results are expressed as the number of dots in transfected cell (at least 20 cells for each treatment) normalized to cell size. Values are presented as mean ...
Inhalation of formaldehyde and xylene induces apoptotic cell death in the lung tissue. The aim of this study was to determine the localization and number of apoptotic cells in lung tissue and bronchus-associated lymphoid tissue (BALT) of newb... Sandikci,M.,Seyrek,... - 《Toxicology & ...
Although the identity of phagocyte receptors that can directly engage PtdSer has remained controversial, recent studies have begun to resolve the conflicting issues and identify new PtdSer recognition receptors. With respect to intracellular signalling within the phagocyte, the RAS homologue (RHO)-family...
The stability of this complex (called lysable complex) will cause DNA damage, thus starting the cell reaction that induces cell cycle arrest and apoptosis [90,91]. Therefore, inhibition of topoisomerase activity is a potential target for tumor therapy [92,93]. Hemanta K. Majumder et al. foun...
eIF5A hypusination controls cell proliferation and has been linked to cancer. eIF5A hypusination requires the enzymes deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase and uniquely depends on the polyamine (PA) spermidine as the sole substrate. Ornithine decarboxylase (ODC) is the rate-...
Human bodies collectively turn over about 200 billion to 300 billion cells every day. Such turnover is an integral part of embryonic and postnatal development, as well as routine tissue homeostasis. This process involves the induction of programmed cell death in specific cells within the tissues an...
We showed that HRK is differentially expressed among established GBM cell lines and that HRK overexpression can induce apoptosis in GBM cells at different levels. This phenotype can be blocked by forced expression of Bcl-2 and Bcl-xL, suggesting the functional interaction of Bcl-2/Bcl-xL and ...