The endosomal sorting complexes required for transport (ESCRT) pathway accessory protein apoptosis linked gene-2-interacting protein X (ALIX) has been shown to be upregulated during dengue virus (DENV) replication. Yeast-two-hybrid screens have additionally shown that ALIX interacts with DENV NS3 ...
ALG-2-interacting proteinX (Alix), also known as AIP1, is a cytoplasmic protein ubiquitously expressed and concentrated in phagosomes and exosomes. Alix may regulate apoptosis since it bindsapoptosis-linked gene 2 (ALG-2), a Ca2+-binding protein necessary for cell death, and also ...
(Pediatr Res 65: 21–26, 2009) Inhibitors of apoptosis proteins (IAPs) are a physiologically widely expressed gene family of apoptotic suppressors ini- tially identified in the baculoviruses (1,2). Subsequently, six human IAPs have been identified including an X-linked in- hibitor of apoptosis...
(Bcl2 Related Protein Long Isoform), and other anti-apoptotic Bcl2 family members reside in the outer mitochondrial membrane and prevent CytoC release. BAX (Bcl2 Associated X-protein), BID (BH3 Interacting Death Domain), and BIM (Bcl2-...
analysis (GSEA) identified that ADCC-resistant cells show an enrichment of genes implicated in the oxidative stress response, independent of known roles of XIAP in apoptosis and proliferation, and corresponding with an increase in the antioxidant pool identified both by gene and protein expression ...
2 To confirm the gene array results, Northern blot analyses were performed to examine XAF1 mRNA expression in WM9 melanoma cells. XAF1 mRNA was not detected in untreated cells but was induced following treatment with IFN-β and IFN-α (Fig. 1 A). The induction of XAF1 protein by both ...
M WB analysis indicated changes in the apoptosis-related gene markers (PARP, Bcl2, Bax) and the ferroptosis-related marker GPX4 after YAP1 inhibition in ES cells. The corresponding original western blots are shown in Fig. S13. N WB analysis of the YAP1 protein expression in siAURKA ES ...
since RIPK1 and RIPK3 have necroptosis-independent functions, it is difficult to decipher the proper role of necroptosis in models using pathway inhibition (e.g., using the RIPK1 inhibitor Nec-1) orRipk1/Ripk3gene deletion approaches. Some studies have already shown a role for RIPK3 in ...
Molecular and epidemiological evidence demonstrate that altered gene expression and single nucleotide polymorphisms in the apoptotic pathway are linked to many cancers. Yet, few studies emphasize the interaction of variant apoptotic genes and their joint modifying effects on prostate cancer (PCA) outcomes....
Knocking out the gene did not influence the mitochondrial DNase activity during PND (Additional File 1, 2). Therefore, the second AIF homolog does not appear to be involved in PND. Discussion In unicellular ciliates, the parental cell-derived cytoplasm is taken over by the progeny nucleus after...