A family of cysteine proteases that are involved in apoptosis and inflammation. Caspases are highly specific for certain protein substrates. For example, caspase-1 processes pro-interleukin-1β (IL-1β) into active IL-1β. Caspases are synthesized in the cell as inactive precursors and are activ...
aWhen the helicopter passed over the house last year,[translate] a时光走廊交谈 Time corridor conversation[translate] aallows a high degree of flexibility in translational activity, the[translate] aproteins involved in apoptosis), and gene expression imbalances.[translate]...
1995. The death domain motif found in Fas (Apo-1) and Tnf receptor is present in proteins involved in apoptosis and axonal guidance. FEBS Lett. 371: 321-323.Hofmann K,Tschopp J.The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis ...
Recent studies have provided evidence that apop- tosis of pancreatic β-cells is important in the early etiology of both type I and type II diabetes mellitus. The mechanisms responsible for induction of apoptosis are unknown, but we present evidence that the signal transduction pathway controlling ...
Many of the recruited proteins are involved in apoptosis control, and may also be directly involved in apoptosis and senescence. The formation of PML nuclear bodies may be modulated by a range of stress-related signalling pathways. Oxidative stress An excess of reactive oxygen species (ROS), ...
In mammalian cells, TA proteins such as those of the Bcl-2 family, BH-3 only and other related proteins are involved in apoptosis. Importantly, this class of proteins is also represented in other cell organelles, in particular, in the ER, the endomembrane system and peroxisomes. The ...
T-2 toxin caused damage to chondrocyte endoplasmic reticulum and mitochondria, leading to impaired cell secretion, decreased secretion of Collagen II and increased chondrocyte apoptosis. Our study confirms that IAPs are involved in cartilage injury induced by T-2 toxin. We found that the decrease in...
Cell stress stimuli can result in outer membrane permeabilization, after which mitochondria release numerous proteins involved in apoptotic signaling, including cytochrome c, apoptosis-inducing factor, endonuclease G, Smac/DIABLO and Omi/HtrA2. Cell fate is determined by signaling through apoptotic ...
Interaction of QT with proteins involved in various signaling pathways has been reported previously16. In this regard, it has also been revealed that QT leads to decrease in cell apoptosis in the hippocampus which is the center of processing the spatial memory and this property can be considered...
Apoptosis and resistance to daunorubicin in human leukemic cells. We compared test methods based on specific mechanisms of daunorubicin (DNR) resistance to more global procedures. Assessment of P-glycoprotein (P-gp) expre... T Efferth,U Fabry,R Osieka - 《Leukemia》 被引量: 398发表: 1997年 ...