is part of the mechanism through which cell contact maintains cell viability, (2) results in the activation (i.e. tyrosine phosphorylation) of the fibroblast growth factor (FGF) receptor, and (3) prevents a sustained elevation in intracellular free calcium ([Ca2+]i) which triggers apoptosis....
et al. TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells. Eur. J. Cancer 42, 1881–1888 (2006). Article CAS Google Scholar Blanco, R., Munoz, P., Flores, J. M., Klatt, P. & Blasco, M. A. Telomerase abrogation dramatically accelerates TRF2-...
Inflammatory bowel disease (IBD), a chronic relapsing gastrointestinal inflammatory disease, mainly comprises ulcerative colitis (UC) and Crohn’s disease (CD). Although the mechanisms and pathways of IBD have been widely examined in recent decades, its
The constructed library was amplified to make DNA nanoballs (DNBs) with more than 200 copies of DNA per molecule. The DNBs were loaded into the patterned nanoarray, and single-end 100-base reads were generated by sequence-based synthesis. The qualified libraries were subjected to paired-end ...
intercellular adhesion molecule-1 and tumour necrosis fac NFkappaB作为不仅作为触发器,而且在APC扮演一个重要角色通过NF upregulation kappaB和antiapoptosis蛋白质Bcl-2在预先处理的期间然后通过激动蛋白质细胞间的黏附力分子1和肿瘤坏死因素阿尔法downregulation在多次灌注液,最后减少caspase-3表示和apoptosis期间[translate...
Caspase-dependent alteration of the ADP/ATP translocator triggers the mitochondrial permeability transition which is not required for the low-potassium-dependent apoptosis of cerebellar granule cells J. Neurochem., 97 (2006), pp. 1166-1181 CrossrefView in ScopusGoogle Scholar [22] W.J. Waddell, ...
Extracellular vesicles (EVs) are tiny membrane vesicles introduced from various cells’ plasma membranes because of activation and apoptosis. Centered on studies, EVs play a role in a variety of procedures, including clot development, vascular harm, and proinflammatory procedures. In the past few year...
(Casp3), a marker of apoptosis [49]. We did not observe any significant difference in Casp3-positive staining between WT andPex2−/−organoids (Fig.2A). We repeated the analysis to probe for apoptosis in MIO using TUNEL staining and confirmed the results obtained for Casp3 staining (Fig...
whether these are released as a result of venipuncture/blood sampling, ex vivo cell death, or are naturally present in the circulation (e.g. from necrosis/apoptosis, minor tissue damage etc.). In addition, it is tempting to hypothesise that heparin triggers toll-like receptor-mediated release...
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain...