Irie F, Masaki KH, Petrovitch H, Abbott RD, Ross GW, Taaffe DR, Launer LJ, White LR: Apolipoprotein E 4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu–Asia Aging Study. Arch Gen Psychiatry 2008, 65: 906–912....
ObjectiveTo investigate the relationship among risk for Alzheimer disease (AD), familial aggregation of AD, and the apolipoprotein E (apoE) ϵ4 allele in
Apolipoprotein E epsilon4 Allele Has No Effect on Age at Onset or Duration of Disease in Cases of Frontotemporal Dementia with Pick- or Microvacuolar-Type HistologyApolipoprotein E epsilon4 Allele Has No Effect on Age at Onset or Duration of Disease in Cases of Frontotemporal Dementia with Pick-...
Controversy exists regarding the apolipoprotein E (ApoE) ε4 allele association with vascular dementia (VaD). The results range from increased ε4 frequency, similar to that found for Alzheimer's disease (AD), to no association at all. Our objective was to clarify the relationship between ApoE ...
The apolipoprotein E (ApoE) 4 allele is strongly associated with Alzheimer's disease (AD), and is, at the same time, a risk factor for cardiovascular disease. Recently, it has also been suggested that skin vessel reactivity is impaired in AD. The aim of this study was to assess the impa...
Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia. di, A., Flevari, P., et al., Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia... E Economou-Petersen,A ...
The patients harbouring the Apolipoprotein E ε4 allele (ApoE4) ( n=9) showed significantly greater vasodilation compared both with patients without the ApoE4 and with controls (one control possessed the ApoE4) when SNP was delivered at the cathode. An additional study of ten of the AD ...
ofAPOE4for AD (i.e., the theoretical reduction in AD incidence in the absence of theAPOE4-coding allele) is around 7% [34]. TheseAPOE4effects enhance genetic anticipation, principally in late-onset AD [35]. Of note, and according to some studies, APOE4 may be a promising therapeutic...
OBJECTIVES The ε4 allele of apolipoprotein E (APOE) represents a major biological risk factor for late onset Alzheimer's disease. However, it is still not known whether the APOE genotype affects the progression of the disease, assessed by different functional methods. METHODS The study sample inc...
载脂蛋白E基因 1. Objective To explore the interaction between EBV infection and the single nucleotide polymorphism of apolipoprotein E gene and the development of Alzheimer's disease(AD). 方法用间接ELISA法测定18例阿尔茨海默病(AD)病人和20例正常对照者血浆中抗EB病毒特异性IgG、IgM类抗体;PCR法检测...