In the absence of LCAT, HDL size did not increase and there was no incorporation of lipid-free apo A-I into the HDL density range. In contrast, when LCAT was present, the particle size of HDL increased and lipid-free apo A-I was incorporated into the HDL such that the HDL apo A-I...
The apoA-I-mediated increase in glucose uptake by HSKMCs was dependent on phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt, the ATP binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-B1). Taken together, these results establish that apoA-I increases ...
Ninety-five percent confidence intervals (CIs) were estimated from the variances that reflect the amount of information underlying each group (including the reference group). As associations were approximately log-linear, regression coefficients were calculated to estimate the HRs associated with 1-SD ...
Maternal serum apolipoprotein A1 (ApoA1) levels, apolipoprotein B (ApoB) levels, and the ApoB/ApoA1 ratio were measured in the first trimester(6–14 weeks), the second trimester(18–28 weeks) and the third trimester(after 28 weeks). We conducted SPSS analysis to evaluate the correlation ...
Applying the 2016 guidelines criteria, in patients with LDL-c within target, 22, 25 and 44% presented non-high-density lipoprotein cholesterol (non-HDL-c), Apolipoprotein B (ApoB) and oxidized LDL-c levels above the recommended range, respectively, whereas according to the 2019 guidelines ...
This was investigated further by selecting several lung tumor patients screened as positive or negative by MRI with SVID present and absent, as well as control CSF as a brain protein reference. Proapolipo- protein A1 was analyzed in these samples on a 2D gel with an expanded pI range (4.7...
Inter-quartile range LDL: Low-density lipoprotein LDLC: Low-density lipoprotein cholesterol Lp[a]: Lipoprotein(a) MAC: Minor allele count MAF: Minor allele frequency NMR: Nuclear magnetic resonance PAV : Protein-altering variant PTV: Protein-truncating variant TRL: Triglyceride-rich lip...
while apoA-I in LpAI:AII increased only less than 30%, from 90 to less than 120 mg/dl, over the same range of HDL-C, regardless of sex and CETP genotype. From the results of the analysis above, it is concluded that human plasma contains constant amount of LpAI:AII particles ...
Since the apo E concentration was chosen to correspond to the range of apo E increase measured in patients treated with dalcetrapib, these results strengthen the implication of the higher level of apo E in HDL in the increase of competition with LDL. These results suggest that apo E-rich ...
However, efficient activation of Vγ9Vδ2 T cells requires millimolar concentrations of IPP, a concentration range that is unlikely to be reached in the extracellular medium in physiological conditions. Thus, tumor cell recognition probably also involves stable cell surface components. In this work, ...