In normal human plasma 5–10% of the total apoA-I exists in a lipid-free or lipid-poor form that accepts cholesterol from peripheral cells expressing the ATP-binding cassette transporter A1 (ABCA1)2. Lipid-free/lipid-poor apoA-I also interacts with scavenger receptor class B type 1 (SR-...
Apolipoprotein A1 Apolipoprotein A-I PDB rendering based on 1av1. Available structures: 1av1, 1gw3, 1gw4, 2a01 Identifiers Symbol(s) APOA1; MGC117399 External
75percent of Apo A in HDL is Apo AI. Levels of Apo AI are inversely related to the risk of coronary heart disease. Apo AI is also thought to activate LCAT (lecithin cholesterol acyl tranferase). In normal plasma, Apo AI levels range from 90-130 mg per 100 ml. Prepared from plasma ...
For example, apolipoprotein(a) is produced in the liver, and can be found in normal and atherosclerotic vessel walls. The compounds of the invention can be utilized in pharmaceutical compositions by adding an effective amount of a compound to a suitable pharmaceutically acceptable diluent or carrier...
Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins HDL biogenesisHDL phenotypesapolipoprotein A-I mutationsapolipoprotein Eapolipoprotein A-IVATP-binding cassette transporter A1(ABCA1)摘要:doi:10.7555/JBR.31.20160082Vassilis I.Zannis[1]Molecular ...
Within the general population, the number of repeated kringle-4 domains appears to range from 15 to 40. This genetic diversity is reflected in the molecular weight variation of mature apo(a), which ranges from 300 to 800 kD (Koschinsky et al., Biochem. (1990) 29: 640-4). In one ...
Normal distribution of the samples was tested using the Shapiro–Wilk test. For statistical analysis, paired or unpaired Student’s t-test, or if appropriate the Mann–Whitney U-test, was used to compare two groups. Two-sided, one-way analysis of variance (ANOVA) followed by post hoc Tukey...
Inter-quartile range LDL: Low-density lipoprotein LDLC: Low-density lipoprotein cholesterol Lp[a]: Lipoprotein(a) MAC: Minor allele count MAF: Minor allele frequency NMR: Nuclear magnetic resonance PAV : Protein-altering variant PTV: Protein-truncating variant TRL: Triglyceride-rich lip...
[104]found that diabetic HDL carries more S1P compared with normal HDL, and thus the diabetic HDL has the potential to contribute to the protective effects on endothelial cells by inducing COX-2 expression and prostacyclin I-2 release. These findings provide new insight into S1P function in ...
The serum level of HDL-C was lower in the ischemic stroke group with a value of 1.03 (IQR, 0.54) (mmol/L), close to the low end of the normal range (0.91–1.92) (mmol/L). The median levels of LDL-C, TG, and TC were not statistically significantly different between the stroke ...