Models containing major gene effect could be rejected./p pConclusion/p pThese results suggest that variations of Apo A1 levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes./p...
In normal human plasma 5–10% of the total apoA-I exists in a lipid-free or lipid-poor form that accepts cholesterol from peripheral cells expressing the ATP-binding cassette transporter A1 (ABCA1)2. Lipid-free/lipid-poor apoA-I also interacts with scavenger receptor class B type 1 (SR-...
29 It was speculated, that the normal metabolism/catabolism may be altered, leading to significant changes in lipoprotein composition and subclasses, producing the amyloid deposition. In the Leu178His mutation, all of the cholesterol-related parameters were within the normal range, the same happening...
The diagnosis is based on elevated TG levels with cholesterol levels that are usually in the normal range [17]. ApoB levels are usually normal as well as LDL-C but carried in smaller, denser particles (Table 1); HDL-C can be markedly reduced despite normal apoA-I. The apoB/apoA-I ...
Applying the 2016 guidelines criteria, in patients with LDL-c within target, 22, 25 and 44% presented non-high-density lipoprotein cholesterol (non-HDL-c), Apolipoprotein B (ApoB) and oxidized LDL-c levels above the recommended range, respectively, whereas according to the 2019 guidelines ...
APOE expression did increase dramatically when intron-3 was deleted from the transfection construct. These data and the results of additional challenging experiments suggested that neuronal expression of theAPOEgene under normal conditions is prevented by the minimal nuclear export of the APOE-I3 mRNA....
Inter-quartile range LDL: Low-density lipoprotein LDLC: Low-density lipoprotein cholesterol Lp[a]: Lipoprotein(a) MAC: Minor allele count MAF: Minor allele frequency NMR: Nuclear magnetic resonance PAV : Protein-altering variant PTV: Protein-truncating variant TRL: Triglyceride-rich lip...
(Fig.1I): those containing non-lipidated apoE (mean diameter ~500–900 nm) were much larger than those containing lipidated apoE (mean diameter ~200-250 nm or less; in diffraction-limited imaging, any aggregates smaller than the diffraction limit will appear in this range) or no apoE...
The serum level of HDL-C was lower in the ischemic stroke group with a value of 1.03 (IQR, 0.54) (mmol/L), close to the low end of the normal range (0.91–1.92) (mmol/L). The median levels of LDL-C, TG, and TC were not statistically significantly different between the stroke ...
RNA interference is provided for inhibition of aquaporin 1 (AQP1) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma. JE Chatterton,RV Patil,NA Sharif,... - US 被引量: 192发表: 2008年 Purification and cha...