Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-...
These results suggest that early-life stress may mediate cognitive impairment in middle-age ApoE4-TR mice through sustained reduction of GABAergic neurons and Reelin expression, which might further diminish the activation of the Fyn/NMDAR2B signaling pathway. 展开 ...
The APOE-4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperfo...
Utilizing female APOE㏕R mice maintained on a high‐fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, recognition memory and spatial memory were assessed using object recognition, Y﹎aze spontaneous alternation, and Barnes...
Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Mol Neurodegener 11, 51.Lin, L. Y. et al. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Molecular neurodegeneration 11, 51, doi:https://doi....
Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. Hippocampus. 2007; 17 :1153–1157.Yun SH, Park KA, Kwon S, Woolley CS, Sullivan PM, et al. (2007) Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice . Hippocampus ...
Dietary Soy β-Conglycinin (7S Globulin) Inhibits Atherosclerosis in Mice Although beta-conglycinin (7S globulin), a major soy storage protein, stimulates the expression of LDL receptors and the degradation of LDL by hepatocytes ... MR Adams,DL Golden,AA Franke,... - 《Journal of Nutrition》 ...
In the present study, we determined the alterations of IgG, CD19, and A尾 in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG. Results Positive staining for ...
Ovariectomy increases sEPSC frequency in female apoE4 TR mice.doi:10.1371/JOURNAL.PONE.0094071.G004C. RebeccaS. ShylaRisher M-LouiseK. ShawnL. RebekahG. HannahH. ScottSwartzwelderD. ScottPLOS ONE
Ovariectomy increases lateral amygdala spine density in female apoE4 TR mice.Rebecca C. KleinShyla SainiMLouise RisherShawn K. AchesonRebekah L. FlemingHannah G. SextonH. Scott SwartzwelderScott D. Moore