Utilizing female APOE㏕R mice maintained on a high‐fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, recognition memory and spatial memory were assessed using object recognition, Y﹎aze spontaneous alternation, and Barnes...
We found that ApoE4-TR mice that underwent the early CUMS procedure displayed cognitive impairment at 12-months-old and exhibited decreased GABAergic neurons in the prefrontal cortex and the dentate gyrus (DG) of the hippocampus. Furthermore, the expression levels of Reelin and its down-stream ...
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation [ J] . Immun Ageing, 2019, 16(1) : 2. [40] Liraz O, Boehm-Cagan A, Michaelson DM. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted ...
Furthermore, APOE4 genotype frequently interacted with the effect of exercise, with APOE4 sedentary mice showing the weakest neuronal and vascular function. Thus, increased physical activity protected against the poor neurovascular function of sedentary APOE4-TR mice. These results provide a potential ...
8. Lanyan Lin, Jing Zhang,et al. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice.Mol Neurodegener. 2016 Jul 12;11(1):51.DOI:10.1186/s13024-016-0107-2 转载须知:“...
Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-...
8. Lanyan Lin, Jing Zhang, et al. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice.Mol Neurodegener. 2016 Jul 12;11(1):51. DOI:10.1186/s13024-016-0107-2 转载须知:“逻辑神经科学”特邀稿件,且作者授权发布;本内容著作权归作者和“逻辑神经科学”...
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation [ J] . Immun Ageing, 2019, 16(1) : 2. [40] Liraz O, Boehm-Cagan A, Michaelson DM. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted ...
Thus, ApoE-TR mice are a good model for investigating the biological function of the human ApoE protein. First, we compared the protein expression of ACE2 in different tissues and found that ACE2 was abundantly expressed in bowel and kidney tissues (Fig. 7B). Furthermore, the inhibition of...
22,23). In particular, APOE4 has been shown to accelerate hippocampal volume loss in human patients24 and to increase neurodegeneration in mice25,26,27,28. APOE4 also increases tau burden in human brains8,9,29,30 and promotes the accumulation of p-tau in human neurons31,32,33 and mouse...