Microalgal Macular Pigment Alleviated the Pathogenic Process in the Streptozotocin-induced Diabetic ApoE-deficient Micedoi:10.1152/physiol.2024.39.S1.262Type 2 diabetes mellitus (T2DM) is one of the fastest growing epidemics in human history and characteristic is insulin resistance (IR), and endocrine ...
Increased plasma levels of IL-1β and IL-18, aggravated macrophage infiltration into atherosclerotic lesions, and accelerated development of atherosclerosis were detected in HHcy mice as compared with control mice, and were associated with the activation of NLRP3 inflammasomes. Silencing the NLRP3 ...
Caprylic acid, Inflammation, TLR4, Atherosclerosis, apoE-deficient miceBackgroundAs reported previously by our group, medium-chain triglycerides can ameliorate atherosclerosis. Given that TLR4 is closely related to atherosclerosis, we hypothesized herein that caprylic acid (C8:0) would suppress inflammation...
Clopidogrel significantly lowers the development of ath- erosclerosis in apoE-deficient mice in vivo. Heart Vessels. 2015 [Epub ahead of print].ChristianHeim, JuliaGebhardt, MartinaRamsperger-Gleixner, JohannesJacobi, MichaelWeyand, Stephan M.Ensminger. (2015) Clopidogrel significantly lowers the ...
Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: a new mechanism of the action of polyphenols. Milenkovic Dragan,Deval Christiane,Gouranton Erwan,Landrier Jean-Fran?ois,Scalbert Augustin,Morand Christine,Mazur Andrzej. PloS one . 2012...
IL-2 and IL-12 with TNF-αas the predominant cytokine in ApoE−/−mice. Concomitantly, TNF-α, IFN-γand MIP-1αwere detected in brochoalveolar lavage (BAL) fluids of these mice, coinciding with lung inflammation consisting primarily of monocytes/macrophages. Such lung inflammation correlate...
Objective To explore the effect of Lctobacillus casei on atherosclerotic plaque formation inapoE-deficient miceand its mechanism in anti-atherogenelsis. 方法将apoE基因缺陷(ApoE-/-)小鼠随机分为4组:对照组(A组)、乳酸杆菌108组(B组)、乳酸杆菌1010组(C组)、乳酸杆菌1012(D组)。
Apolipoprotein (apo) E-deficient mice develop severe hypercholesterolemia and have lesions that progress from fatty streaks to fibrous plaques distributed in lesion-prone areas throughout the aorta. Lesions develop in apoE-deficient mice on a regular chow diet and will occur faster on a diet higher...
OBJECTIVE: We tested the hypothesis that hyperhomocysteinemia and hypercholesterolemia promote arterial thrombosis in mice. METHODS AND RESULTS: Male apolipoprotein E (Apoe)-deficient mice were fed one of four diets: control, hyperhomocysteinemic (HH), high fat (HF), or high fat/hyperhomocysteinemic...
1) apolipoprotein E-deficient mice ApoE基因缺陷小鼠1. OBJECTIVE To investigate the effect of water extractives of Qixue Bingzhi Fang(CWQB) on atherosclerotic labilization plaque pathology and ultrastructure(36 weeks),MMP-1 and TIMP-1 activity in apolipoprotein E-deficient mice(ApoE-mice). 目的...