Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Mol Neurodegener 11, 51.Lin, L. Y. et al. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Molecular neurodegeneration 11, 51, doi:https://doi....
These results suggest that early-life stress may mediate cognitive impairment in middle-age ApoE4-TR mice through sustained reduction of GABAergic neurons and Reelin expression, which might further diminish the activation of the Fyn/NMDAR2B signaling pathway.Back...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, ...
The APOE-4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperfo...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
Estradiol enhances long term poten- tiation in hippocampal slices from aged apoE4-TR mice. Hippocampus 2007;17(12):1153-7.Yun SH, Park KA, Kwon S, Woolley CS, Sullivan PM, Pasternak JF, Trommer BL. Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. ...
Subcortical white matter ischemic stroke or sham procedures were performed on human ApoE4-targeted-replacement (TR):5XFAD mice at 8weeks of age. Behavioral tests were done at 7, 10, 15, and 20weeks. A subset of animals underwent 18 FDG-PET/CT. At 20weeks of age, brain tissue was ...
APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD OBJECTIVE: To test the hypothesis that the e4 allele of APOE is associated with a region-specific pattern of brain atrophy in AD. METHODS: Volumes of the h... A Beltramello,H Soininen,C Geroldi,....
Ovariectomy increases sEPSC frequency in female apoE4 TR mice.doi:10.1371/JOURNAL.PONE.0094071.G004C. RebeccaS. ShylaRisher M-LouiseK. ShawnL. RebekahG. HannahH. ScottSwartzwelderD. ScottPLOS ONE
The allele 4 of apolipoprotein E (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD) and is therefore a promising therapeutic target. Human and animal model studies suggest that apoE4 is hypolipidated; accordingly, we have previously shown that the retinoid X ...