2p表达相关的并且与非家族性迟发性阿尔茨海默氏病有关的症状或体征,其中该小鼠的基因组包括:1)可操作地与启动子连接的编码人APOE4蛋白(APOE4p)的DNA序列;和2)可操作地与启动子连接的编码具有突变p.R47H的小鼠Trem2蛋白(Trem2p)的DNA序列,使得小鼠表达人APOE4p和小鼠Trem2p.提供了使用这种遗传修饰小鼠筛选用于...
具有一种或多种与人APOE4p和小鼠Trem2p表达相关的并且与非家族性迟发性阿尔茨海默氏病有关的症状或体征,其中该小鼠的基因组包括:1)可操作地与启动子连接的编码人APOE4蛋白(APOE4p)的DNA序列;和2)可操作地与启动子连接的编码具有突变p.R47H的小鼠Trem2蛋白(Trem2p)的DNA序列,使得小鼠表达人APOE4p和小鼠Trem2p...
1.一种遗传修饰小鼠,其具有一种或多种与人apoe4p和小鼠trem2p表达相关的并且与非家族性迟发性阿尔茨海默氏病有关的症状或体征,所述小鼠的基因组包含:1)可操作地与启动子连接的编码人apoe4蛋白(apoe4p)的dna序列;和2)可操作地与启动子连接的编码具有突变p.r47h的小鼠trem2蛋白(trem2p)的dna序列,其中所述小鼠...
具有一种或多种与人APOE4p和小鼠Trem2p表达相关的并且与非家族性迟发性阿尔茨海默氏病有关的症状或体征,其中该小鼠的基因组包括:1)可操作地与启动子连接的编码人APOE4蛋白(APOE4p)的DNA序列;和2)可操作地与启动子连接的编码具有突变p.R47H的小鼠Trem2蛋白(Trem2p)的DNA序列,使得小鼠表达人APOE4p和小鼠Trem2p...
A loss-of-function R47H mutation in TREM2 is also one of the strongest single allele genetic risk factors for AD [2,3], providing a link between microglia dysfunction and AD pathogenesis. TREM2 encodes a single-pass type I membrane protein that forms a receptor-signaling complex with the ...
(E3/Trem2ko); and APOE4+/+/Trem2−/−(E4/Trem2ko) mice. AllAPOE3orAPOE4mice were littermates and fed normal mouse chow diet ad libitum. Mice had water accessible at all times and were kept on a 12-h light-dark cycle. Male and female mice from each genotype were used for ...
The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). E
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration J. Clin. Invest., 130 (2020), pp. 4954-4968 CrossrefView in ScopusGoogle Scholar Habib et al., 2020 N. Habib, C. McCabe, S. Medina, M. Varshavsky, D. Kitsberg, R. Dvir-Szternfeld, G. Green, D...
2) operatively connected to the promoterContains a DNA sequence encoding a mouse TREM2 protein (trem2p) with a p.r47h mutation.This causes the mouse toExpressing human apoE 4P and mouse trem2pGenetically modified mice are provided.Such genetically modified mice are used to provide a method ...
We also observed age related changes, specifically in Trem2*R47H mice, such as more differentially expressed genes and significant differential splicing events compare to the APOE4mouse models.Further, these mouse models overlapped with immune, myelination, neuronal, and DNA repair related AMP〢D ...