近日,西班牙圣十字圣保罗医院的科研人员在Nature Medicine发表了题为“APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease”的文章。研究团队分析了美国国家阿尔茨海默病协调中心(NACC)的大型病理数据集,以及迄今为止发表的5个大型多中心队列10,039人的AD生物标志物数据。分析结果发现,APOE4...
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating Center a...
近日,来自西班牙巴塞罗那圣十字圣保罗医院的Víctor Montal研究团队在Nature Medicine杂志发表题为APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease的研究论文,该研究利用来自国家阿尔茨海默病协调中心(NACC)的大型病理数据...
George Andrew S. Inglis Corresponding author Correspondence to George Andrew S. Inglis. Rights and permissions Reprints and permissions About this article Cite this article Inglis, G.A.S. Exploring how APOEε4 increases Alzheimer’s disease risk in women. Nat Aging 4, 1032 (2024). https://doi...
The inheritance of Apolipoprotein E4 ( APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports...
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimer’s disease pat
The strongest genetic risk factor for Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (ApoE ε4). A high fat diet also adds to the risk of dementia and AD. In addition, there are sex differences as women carriers have a higher risk of an earlier onset and rapid declin...
Alzheimer's disease(AD)is the most common cause of dementia and presents with an insidious onset and long prodromal period.Despite billions spent on clinical trials and decades of research,there are currently no disease modifying therapies approved for AD.Two of the most well-appreciated risk facto...
Alzheimer’s disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative "ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative." Neurology. 1997 Jan;48(1):139-47.Blacker D, Haines JL, Rodes L,... D Blacker,JL Haines,L Rodes,... - 《Neurology》 被引...