APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...
Alzheimer's diseaseImmunologyMicrobiologyNeurodegenerationSignals from gut microorganisms to the brain might be involved in neurodegeneration. It emerges that the geneAPOE— variants of which each confer a different risk of Alzheimer's disease — has a role in modulating this gut–brain communication.#...
Individuals carrying one form of the APOE gene, APOE4, have a greater risk of developing Alzheimer disease than individuals with other forms of the APOE gene (APOE2 and APOE3). In the study, the proteins generated by the different forms of the APOE gene were found to differentially affect ...
APOE基因有2个突变位点,可产生3种等位基因ε2、ε3、ε4,6种基因型ε2/ε2、ε2/ε3、ε2/ε4、ε3/ε3、ε3/ε4、ε4/ε4,分别编码三种载脂蛋白亚型ApoE2、ApoE3和ApoE4,不同亚型在阿尔茨海默病(Alzheimer’s disease,AD)、血脂代谢,以及动脉粥样硬化等心脑血管...
Consequently, these gene expression levels were increased to a lesser extent in ApoE4 TR mouse brains (Figure 6G), suggesting that ApoE4 mice are less competent to consolidate fear memory. We next asked whether the isoform-dependent effect in regulating cholesterol metabolism and histone acetylation...
Further studies to clarify this interaction may improve our understanding of the generic risks for AD. Copyright © 2005 S. Karger AG, Basel 展开 关键词: Alzheimer disease Apolipoprotein E Estrogen Estrogen-metabolizing gene polymorphism DOI: 10.1159/000082663 被引量: 45 年份: 2005 ...
②Nature:APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia APOE4/4与阿尔茨海默症小胶质细胞损伤性脂滴相关 拓展:这项研究基于单核RNA测序技术,揭示了阿尔茨海默病的遗传风险因素与小胶质细胞脂滴积累和神经毒性小胶质细胞衍生因子之间的联系,可能为阿尔茨海默病提供治疗策略。APOE4(...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
Chromosome 19q13.32 is a gene rich region, and has been implicated in multiple human phenotypes in adulthood including lipids traits, Alzheimer's disease, and longevity. Peroxisome Proliferator Activated Receptor Gamma (PPARγ) is a ligand-activated nuclear transcription factor that plays a role in ...
APOE; promoter polymorphism; Alzheimer’s disease; ethnic variability; brain atrophy; genetic association1. Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized clinically by dementia and memory loss. It is the most common cause of dementia in the elderly, ...