The APC (adenomatous polyposis coli) gene is responsible for familial adenomatous polyposis and is also associated with the development of sporadic tumors of the colon and stomach. To investigate whether or not mutations of APC play any role in tumors arising in other organs, we examined somatic ...
Somatic mutations of the APC gene in eight cancer cell lines, twelve adenomas and sixteen intestinal metaplasias of the stomach were examined. The expression of the APC mRNA and protein in eight cancer cell lines was also investigated. PCR-SSCP analysis detected mutations of the APC gene in 25...
Human CD355 is involved in immunosurveillance of cancer cells, gamma delta T cell survival, cell polarity, retention of lymphocytes in lymph nodes, promotion of cytotoxicity in NK cells, and IFN gamma secretion from CD8+ T cells. Cr24.1 has been reported to have antagonist activity....
preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and ...
To further explore the role of theAPC/β-cateninpathway in breast carcinogenesis, we investigated the status ofAPCgene promoter methylation in primary breast cancers and in their non-cancerous breast tissue counterparts, as well as mutations of theAPCand β-cateningenes. Hypermethylation of theAPC...
The present study suggested that the increase in Wnt activity in certain cervical cancer-derived cells may be associated with an alteration in the methylation status of the APC gene promoter 1A. 展开 关键词: cervical cancer DNA methylation adenomatous polyposis coli β-catenin Wnt signaling pathway ...
Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine ...
Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 This is...
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene associated with both familial and sporadic cancer. Despite high rates of allelic loss ... A.K. Virmani,A Rathi,U.G. Sathyanarayana,... - 《Clinical Cancer Research》 被引量: 730发表: 2001年 Adenomatous Polyposis Coli (...
Detectionofmutationatexon15ofAPCgeneingastriccancerwithmultiplexPCRandDNAsequencing FANGDian2chun,LUOYuan2hui,YANGShi2ming,LIXiao2an,LINGXian2long(FANGLi)LIUWei2wen(DepartmentofGastroenterology,SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing400038,China) ...