GENETIC mutationEMBRYONIC stem cellsORGANOIDSFamilial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation ...
[8] Cleary SP, Kim H, Croitoru ME, Redston M, Knight JA, Gallinger S, Gryfe R. "Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk". Dis Colon Rectum.51 (2008):1467-1473; discussion 1467-1473. [9] Leber, M. F., Efferth, T."Molecular principles...
et al. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res. 54, 3011–3020 (1994). CAS PubMed Google Scholar Ichii, S. et al. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous...
We identify NOTUM as a key mediator during the early stages of mutation fixation that can be targeted to restore wild-type cell competitiveness and provide preventative strategies for people at a high risk of developing colorectal cancer.This is a preview of subscription content, access via your ...
Malignant tumor of colon; Transitional cell carcinoma of bladder; Hereditary nonpolyposis colorectal carcinoma; Rectal Neoplasms; Increased gastric cancer; Adrenocortical carcinoma; Lipoma; Increased hepatocellular carcinoma risk; Increased incidence of hepatocellular carcinoma; Astrocytoma; Adenoma; Hyperlipidemia;...
Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to...
thymidinekinase.SignificantShmt1-dependentchangestomethylationcapacity,geneexpression andpurinesynthesiswerenotobserved.Shmt1hemizygositywasassociatedwithincreasedrisk forintestinalcancerinApc min/+ micethroughagene-by-dietinteraction,indicatingthatthe capacityforthymidylatesynthesismodifiessusceptibilitytointestinalcancerin...
Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk Dis Colon Rectum., 51 (2008), pp. 1467-1474 CrossrefView in ScopusGoogle Scholar [26] A.T. Weeraratna, Y. Jiang, G. Hostetter, K. Rosenblatt, P. Duray, M. Bittner, J.M. Trent Wnt5a signaling ...
Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells...
5. A method of identifying candidate drugs for use in FAP patients, patients with APC or β-catenin mutations, or patients with increased risk of developing colorectal cancer, comprising the steps of: contacting a Tcf-responsive reporter gene with a test compound under conditions in which the ...