Reports that progression to duodenal cancer cannot be predicted from germline mutation of the APC gene in patients with familial adenomatous polyposis. Key issues of interest; Analysis of pertinent topics and relevant issues; Theoretical significance to medical genetics....
et al. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res. 54, 3011–3020 (1994). CAS PubMed Google Scholar Ichii, S. et al. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous...
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling1, but reduced secretion of WNT ligands increases the ability of Apc-mutant intestinal stem cells to colonize...
APCmin基因信息:疾病概述家族性腺瘤性息肉病(Familial Adenomatous Polyposis,FAP)是结直肠癌发生的癌前病变,患者结直肠部位多发成百上千个腺瘤性息肉,抑癌基因APC的突变是结直肠肿瘤的起始因素。Dove实验室于1…
APC genecolorectal cancerFAPFamilial adenomatous polyposis (FAP) is an autosomal dominant condition characterized by diffuse intestinal polyposis, specific gene mutation, and predisposition for developing colon cancer. Left untreated, patients with FAP will develop colorectal carcinoma during early adulthood. ...
Patients with FAP develop hundreds to thousands of adenomatous polyps in the colon and rectum during their 2nd or 3rd decades, and one or more of them progress to cancer if left without surgical treatment. The gene responsible for FAP was identified in 1991 and termed the APC (adenomatous ...
[8] Cleary SP, Kim H, Croitoru ME, Redston M, Knight JA, Gallinger S, Gryfe R. "Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk". Dis Colon Rectum.51 (2008):1467-1473; discussion 1467-1473. ...
The APC gene is located at chr5q21 and is expressed in many tissues throughout the human body. In the colorectal epithelium in particular, APC functions as a critical suppressor of cancer initiation. Individuals who inherit inactivating mutations in one
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Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transfor