(2010) Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons. Gut, 59, 496-507.Zilberberg, A., Lahav, L., Rosin-Arbesfeld, R. 2010. Restoration of APC gene function in colorectal cancer cells by ...
The APC gene is regarded as the gene for colorectal cancer as it is found mutated in most sporadic cases regardless of the histological stage. APC encodes a multifunctional protein that is involved in several processess, including signal transduction, cell adhesion and migration, proliferation, apopt...
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling1, but reduced secretion of WNT ligands increases the ability of Apc-mutant intestinal stem cells to colonize...
[8] Cleary SP, Kim H, Croitoru ME, Redston M, Knight JA, Gallinger S, Gryfe R. "Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk". Dis Colon Rectum.51 (2008):1467-1473; discussion 1467-1473. [9] Leber, M. F., Efferth, T."Molecular principles...
Background & Aims: Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews. However, a second study ind...
A new conditional Apc-mutant mouse model for colorectal cancer Carcinogenesis., 31 (2010), pp. 946-952 Google Scholar [10] A. Zilberberg, L. Lahav, R.R. Arbesfeld Restoration of APC gene function in colorectal cancer cells by aminoglycoside and macrolide induced read through of premature ter...
Since the alteration of the APC gene occurs early in most colorectal tumors, the detection of APC mutations in fecal tumor DNA by HD-PCR may be a powerful tool in non-invasive cancer diagnostics. Hum Mutat 11:84–89, 1998. © 1998 Wiley-Liss, Inc. Get PDF (204K) More content lik...
Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to...
8.结直肠癌(colorectal cancer,crc)是发达国家癌症相关死亡的第二大原因,并且每年导致全球超过600,000人死亡。crc从腺瘤到腺癌以及最终侵袭性和转移性疾病的演变受获得标志性遗传改变的控制,最显著的是腺瘤性结肠息肉病(adenomatous polyposis coli,apc)和p53肿瘤抑制因子的失活以及kras癌基因的激活(orchard et al.,20...
Malignant tumor of colon; Transitional cell carcinoma of bladder; Hereditary nonpolyposis colorectal carcinoma; Rectal Neoplasms; Increased gastric cancer; Adrenocortical carcinoma; Lipoma; Increased hepatocellular carcinoma risk; Increased incidence of hepatocellular carcinoma; Astrocytoma; Adenoma; Hyperlipidemia;...