Mutation of the AP1 motif in the context of the intron enhancer was shown to decrease enhancer-mediated activation of the promoter in both pre-B cells induced with LPS and constitutive expression in mature B cells.doi:10.1093/nar/22.24.5425Schanke Judith T....
d, Tile plot showing Reactome pathways enriched among upregulated genes with a predicted AP1 motif (FDR < 0.05). Presence of a colored tile indicates enrichment at a given post-injury time. Tile opacity encodes significance. Color corresponds to the parent process, as defined by the ...
其中, (A)SP1的Motif图; (B)通过JASPAR预测lncRNA AFAP1‑AS1启动子序列中的SP1结合位点; (C)ChIP测定证实SP1与P3处的lncRNA AFAP1‑AS1启动子区结合; (D)通过蛋白质印迹证实了ov‑SP1载体对SP1的过度表达; (E)通过双荧光素酶测定法测定结合位点P3。
Mutation of either AP1 motif on the BCSG1 promoter constructs markedly reduces the promoter activity. We further show that 12- O -tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites. The effect of TPA on ...
Specific nuclear factor-DNA complexes formed within the promoters and enhancers are essential for transcriptional regulation. For eukaryotic systems, however, some DNA motif(s) are capable of binding to a family of related factors, thus making it difficult to identify the factor actually binding on ...
The ETV4-MED25 interaction involves two domains, the N-terminal activation domain (AD) and the DNA-binding domain (DBD), each binding the activator interacting domain (ACID) of MED25 via a similar motif (ΩxxxΩΦ or ΦΩxxxΩ, where Ω is an aromatic residue, Φ is a hydrophobic ...
其中,(A)SP1的Motif图;(B) 通过JASPAR预测lncRNA AFAP1‑AS1启动子序列中的SP1结合位点;(C)ChIP测定证实SP1与 P3处的lncRNA AFAP1‑AS1启动子区结合 ;(D)通过蛋白质印迹证实了ov‑SP1载体对SP1的过 度表达;(E)通过双荧光素酶测定法测定结合位点P3。 [0020] 图3为SP1促进lncRNA AFAP1‑AS1介导的...
The results of MeRIP-seq showed that the GGACU motif was highly enriched in the immunopurified mRNA of our sample (p = 1e-36) (Fig. 4C), and most of the m6A-related peak reduction caused by METTL3 knockdown was concentrated in the 3′ and 5′ UTR regions of mRNA (Fig. S3J)...
This RAD51AP1 motif is reminiscent of the FVPP motif in the tumor suppressor protein BRCA2 that mediates DMC1 interaction. These results further implicate RAD51AP1 in meiotic HR via RAD51 and DMC1. 展开 关键词: Humans Cell Cycle Proteins DNA-Binding Proteins BRCA1 Protein Recombinant Proteins...
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