This family of genes encodes the AP transcription factors where the binding motif is well conserved but other sequences may vary. These proteins bind to 5′-TGANTCA-3′ consensus in DNA. AP2 binds only to TC-II but not to TC-I of the two identical and adjacent TC motifs (5′-TCC...
The most significantly enriched transcription factor motifs in HA-specific open chromatin peaks belonged to the AP1 family, suggesting AP1 factors may play an integral role in mediating exhaustion. RNA-seq and western blot confirmed increased expression of AP1 factors in exhausted CAR T cells. ...
We designed a CRISPR library to target the FOS/JUN motifs in the OIS-induced REs. For 398 of the 638 OIS-induced REs with the FOS/JUN motif, we found an occurrence of the NGG PAM in a location that is expected to induce a Cas9 DNA cleavage within a margin of 5 bp with respect to...
AP1-motifs, which bind JUN and FOS transcription factor families, were observed in MED25-occupied regions and JUN/FOS also contact MED25; FOS strongly binds to the same MED25 site as ETV4 AD and JUN interacts with the other two MED25 sites. In summary, we describe features of the ...
However, several DAZAP1-binding motifs (that is, three ISS groups) were also recognized by highly expressed splicing inhibitors of the hnRNP A1 family10, thus these motifs show splicing silencer activity despite recognition by DAZAP1. The overlap of RNA-binding specificity between splicing factors ...
The typical structure of IκB proteins are the presence of five to seven ankyrin repeat motifs, which serve as binding domains for the interaction with RHD of NF-κB proteins (Jacobs and Harrison, 1998). Among them, particular important is IκBα which is best-characterized and plays a ...
Sp1binds to guanine/cytosine (GC)-rich motifs of many promoters and is involved in many cellular processes, including cell differentiation, growth, and apoptosis; immune responses; response to DNA damage; and chromatin remodeling. It is overexpressed in multiple tumors and is a negative prognostic ...
低密度 脂蛋白受体相关蛋白(LRP)是一种内吞蛋白,属于低密度脂蛋白受体(LDLR) 基因家族。低密度脂蛋白受体相关蛋白的伴侣蛋白即受体相关蛋白(receptor associated 族受体由内质网向胞膜运输、正确折叠成熟及成熟过程中免受其他配体结合的攻 击起至关重要的作用。RAP与LRP有高度的亲和性,当RAP与LRP结合时,能 够阻止...
JUND showed the greatest potential to bind to AP1 motifs (Fig.S3E, F). But in general, individually silencing a single subunit did not significantly downregulateDKK1, due to the unique redundancy effect of the AP1 family. Although we attempted various combinations of JUND and FOS family subunits...
JunD is capable of forming homo as well as hetero dimers: when forming hetero dimers with the Jun/Fos family it prefers the TRE motif, while with the ATF family it prefers CRE motifs. However, by sequence analysis of TF binding motifs, it is not possible to sub-classify the members of ...