Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif 目的: berberine.Methods 完成证实人的肺的巨大的房间癌房间的增长上的小檗硷的镇压效果衬里 PG 并且在 antitumoral 后面表明机制: PG 房间的增生的效果被 3-(4,5-dim... Y Luo,Y Hao,TP...
然后,作者通过流式细胞术分选出eGFP + 细胞,并进行ATAC-seq和转录因子足迹分析。与体外结果一致(图5a),作者发现AP-1家族成员是PD-1缺陷细胞中富集的顶级motif(图5g)。令人惊讶的是,在ACLY药物抑制的情况下,与完整的PD-1通路相比,Pdcd1缺失细胞中的AP-1足迹被减少(图5h)。 总的来说,作者基因定义的小鼠模型...
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. Acta Pharmacol Sin. 29(5):628-33(2008). [5] Gaudio E, et al. Physical association with WWOX suppresses c-Jun transcriptional activity.Cancer Res. 66(24):11585-9 (2006). ...
Here, our study shows the discovery of a glutamine-based motif that resembles a tyrosine-based motif within the C-terminal region of RNF13 that binds to the clathrin adaptor protein complex AP-1, notably without a functional interaction with AP-3. Using biochemical, molecular and cel...
We also noted requirement of the LI motif of the LGP85 tail in binding to the AP-1 complex. Our data and others which indicated the binding of AP-3 to the LIMP II (synonym of LGP85) tail suggest that the cytoplasmic tail of LGP85 interacts with AP-1 at the trans-Golgi network (...
Motif logos are shown. Black, dotted boxes highlight core AP-1 TF-motif. Note that transcriptional repressor BACH shares AP1-motif. Data in (b-i) are collected from 2 biologically independent experiments. j, ATAC-seq (grey lines-forward, black lines-reverse reads) and nucleosome density (...
3.2. ICC-specific super enhancers affect gene expression in ICC and the region of different histone modification patterns are enrichment in sites of AP-1 motif As shown inFig. 2, we first identify Super-Enhancers (SEs) using H3K27ac in the genomes of HIBEpiC, SSP-25, HUCCT1, CCLP-1, ...
The AP-1 and ATF/CREB families of eukaryotic transcription factors are dimeric DNA-binding proteins that contain the bZIP structural motif. The AP-1 and AT... J Kim,K Struhl - 《Nucleic Acids Research》 被引量: 813发表: 1995年 Placental vascularisation requires the AP-1 component fra1 Fr...
To identify BATF-containing TF complexes in ALCL, we first analyzed AP-1 DNA binding at the classical AP-1 5ʹ-TGA[G/C]TCA-3ʹ motif (Supplementary Figure1A, top) in a panel of ALK+and ALK–ALCL and T-cell-derived control (non-ALCL) cell lines already used in our previous stud...
Moreover, mmp9 expression is driven by the transcription factor AP-1 and differences in mmp9 transcription between virulent and attenuated Theileria-transformed macrophages is due to differential recognition of the AP-1 motif in the mmp9 promoter38. Significantly, a fast migrating AP-1 family ...