Furthermore, we identify a novel subtype of AP-1-binding motif within Gadkin that specifically associates with the gamma1-adaptin ear domain. Mutational inactivation of this novel type of motif, either alone or in combination with three more conventional AP-1gamma binding peptides, causes Gad...
Motif analysis of peaks from ATAC-seq and ChIP-seq Motif analysis on peak regions was performed using HOMER function findMotifsGenome.pl with default parameters to calculate the occurrence of a TF motif in peak regions compared to that in background regions. We used -log10 (p-value) to rank...
Mutations within this motif reduce the ability of RNF13 to interact with AP-3. Here, our study shows the discovery of a glutamine-based motif that resembles a tyrosine-based motif within the C-terminal region of RNF13 that binds to the clathrin adaptor protein complex AP-1, notab...
Here we report two different in vitro analyses (affinity beads and surface plasmon resonance) which revealed specific interaction between the cytoplasmic tail of LGP85 and AP-1 but not so with AP-2. We also noted requirement of the LI motif of the LGP85 tail in binding to the AP-1 ...
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif 目的: berberine.Methods 完成证实人的肺的巨大的房间癌房间的增长上的小檗硷的镇压效果衬里 PG 并且在 antitumoral 后面表明机制: PG 房间的增生的效果被 3-(4,5-dim... Y Luo,Y Hao,TP...
所有蛋白均含有Motif1和Motif4,表明Motif1和Motif4是构成AP2/ERF结构域的主要基序。同时,相同亚家族基因的保守基序呈现高度相似性,这可能导致这些亚家族成员具有类似的生物学功能。AP2亚家族成员都具有2个Motif1;5个RAV亚家族成员的保守基序较多,都含...
ETS proteins share as their unifying domain an ETS DNA binding motif, a variant of the winged helix-turn-helix motif that not only mediates binding to the DNA, but can also mediate protein-protein interactions15. In order to test if the Ets21C DNA domain was necessary for target gene activ...
所有蛋白均含有Motif1和Motif4,表明Motif1和Motif4是构成AP2/ERF结构域的主要基序。同时,相同亚家族基因的保守基序呈现高度相似性,这可能导致这些亚家族成员具有类似的生物学功能。AP2亚家族成员都具有2个Motif1;5个RAV亚家族成员的保守基序较多,都含有Motif1、Motif3、Motif4、Motif5、Motif6、Motif7;大部分ERF和...
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. Acta Pharmacol Sin. 29(5):628-33(2008). [5] Gaudio E, et al. Physical association with WWOX suppresses c-Jun transcriptional activity.Cancer Res. 66(24):11585-9 (2006). ...
Formation of AP-1/σ1A-ArfGAP1-Rabex-5 complexes is prevented by σ1B binding of Rabex-5 and the amount of endosomal Rabex-5 is reduced. AP-1 complexes differentially regulate endosome maturation and coordinate protein recycling and degradation, revealing a novel molecular mechanism by which ...