B cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). We analysed two independent cohorts of healthy donors and SLE patients using a combined approach of flow and mass cytometry. We have found that IgD-CD27+ switched and atypical IgD-CD27- memory B cells, ...
Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning? Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease for which therapeutic advances in immunosuppressive and support therapy have significan... I Calero,I Sanz - 《Discovery Medicine...
BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen- experienced B cells. Semin. Immunol. 18: 297-304... Laura,S.,Treml,... - 《Seminars...
Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Egui, AdrianaCarmen Thomas, MCarrilero, BartoloméSegovia, ManuelAlonso, CarlosMarañón...
the cells were transferred from 6-well plates to 75-cm2flasks. The cells were maintained for 14 days before harvesting. B. Calibration for sorting and post-evaluation. Upper panel, the percentage of cells defined by square in Tem and Tcm was sorted; middle panel, post-sort re-evaluation; ...
Ag-experienced B cells including memory cells, plasmablasts, and Ab-secreting cells were expanded in the pediatric anti-NMDAR-AE cohort, but not in the controls. These Ag-experienced B cells in the cerebrospinal fluid of a pediatric case of NMDAR-AE that was refractory to treatment had ...
BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity ...
Immunohistochemistry revealed considerable T and B cell infiltrates and lymphoid follicles with germinal center-like structures within the tumor microenvironment. Flow cytometry demonstrated that populations of antigen-experienced CD4+ and CD8+ cells were present, as well as an enrichment of regulatory T ...
BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen- experienced B cells. Semin. Immunol. 18: 297-304.Treml LS, Crowley JE, Cancro MP. (2006).BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen-experienced B ...
Altered composition of the B cell compartment in the pathogenesis of systemic lupus erythematosus (SLE) is characterized by expanded plasmablast and IgD–CD27– double‐negative B cell populations. Previous studies showed that double‐negative B cells represent a heterogeneous subset, and further ...