Ag-experienced B cells including memory cells, plasmablasts, and Ab-secreting cells were expanded in the pediatric anti-NMDAR-AE cohort, but not in the controls. These Ag-experienced B cells in the cerebrospinal fluid of a pediatric case of NMDAR-AE that was refractory to treatment had ...
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to en...
BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity matura...
Our studies also show that transiently antigen-experienced B cells are not rendered unresponsive to restimulation with antigen following functional and phenotypic inactivation. Transiently pulsed and then inactivated B cells have similar capacity as naive B cells to join GC and PC responsesin vivoupon ...
Autoimmune diabetes-prone NOD mice display a unique set of antigen-experienced ???CD4lo??? T cells that persist after primary stimulation. Here, we report that a population of such cells remained after secondary and tertiary TCR stimulation and produced cytokines upon antigenic challenge. However,...
Changes in immature B cell reactivity to antigen associated with reduced surrogate light chain are also seen in the peripheral B cell populations. 3) Age-associated B cells represent "self-reactive" antigen experienced B cells, provide "feed-back" inhibition of B lymphopoiesis, and promote a "...
et al. Antigen experienced T cells from peripheral blood recognize p53 neoantigens. Clin. Cancer Res. 26, 1267–1276 (2020). CAS PubMed PubMed Central Google Scholar Sharkey, M. S., Lizee, G., Gonzales, M. I., Patel, S. & Topalian, S. L. CD4+ T-cell recognition of mutated ...
Selective Activation of Antigen-Experienced T Cells by Anti-CD3 Constrained on Nanoparticles Activation of T cells through the TCR is mediated by the TCR-CD3 signaling complex. Cross linking of this complex with Abs directed against CD3 leads to po... YC Lo,MA Edidin,JD Powell - 《Journal of...
matureB lymphocytes, with low nonhematopoietic tissue andhematopoietic stem cellslevels. It is indispensable in order to function bone marrow plasma cells which were known to be long lived.28-31BCMA, in conjunction with the other 2 functionally active parts of the TNFR superfamily, BAFF; B cell...
Initiation of an adaptive immune response requires that naive (nonantigen experienced) T cells detect their cognate antigen displayed by a professional antigen-presenting cell. The process by which antigen is acquired and displayed to T cells is termed ‘antigen presentation.’ Antigen presentation can...