Like several other tumor types, these intracranial tumors often harbor an immune cell infiltrate that can include substantial numbers of B cells. Characteristic details of the B cell infiltrate remain undefined. To gain a deeper understanding of both the B cell repertoire and insight into the role...
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to en...
Improved antibody responses by class-switched memory B cells require enhanced signaling from their antigen receptor (BCR) in a coreceptor-independent manner. However, all BCR classes on newly generated and antigen-experienced B cells utilize the canonical Ig伪/Ig尾 subunit for signaling via the ...
S1B. Antigen-experienced B cells (CD19+CD27+) were sorted, and double negative controls were utilized to gate the toxin- and non-binding cells: unlabeled toxin and the non-conjugated anti-His APC (BioLegend) for DT and TT, or non-conjugated Alexa Fluor 647 (Invitrogen) for PT. ...
Our studies also show that transiently antigen-experienced B cells are not rendered unresponsive to restimulation with antigen following functional and phenotypic inactivation. Transiently pulsed and then inactivated B cells have similar capacity as naive B cells to join GC and PC responsesin vivoupon ...
36 Thus, expression of adhesion molecules and chemokine receptors determine homing and dissemination of normal and malignant B cells. To explore to what extent FLs of the small intestine resemble their nodal counterparts and on the other hand to explain their localized nature, we performed a ...
翻译 antigen-experiencedcells 翻译 抗原经验细胞 以上结果来自机器翻译。 释义
BCMA-targeted CAR T-cells transformed the treatment of relapsed and refractory multiple myeloma (RRMM), yet improvements are needed in manufacturing, toxicity and efficacy. We conducted a phase 1 clinical trial of BMS-986354, an autologous BCMA CAR T man
By six months, 68% of patients retained CTL019 cells, and 73% experienced sustained B-cell aplasia. While all patients developed CRS, which was effectively treated with tocilizumab and was more common in patients with a higher disease burden pre-infusion.Citation69 The ongoing trials are ...
We next assessed whether Ova-specific B cells experienced antibody class switch recombination based on their surface expression of IgD and IgM where isotype-switched B cells lose expression of IgD or IgM on the cell surface (Fig. 2d). When isotype switching was examined over the 56-day time ...