抗原刺激的。。。比如 antigen-experienced T cells,就是抗原刺激过的T 细胞！
B cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). We analysed two independent cohorts of healthy donors and SLE patients using a combined approach of flow and mass cytometry. We have found that IgD-CD27+ switched and atypical IgD-CD27- memory B cells, ...
CD4lo??? T cells differentiate into effector T cells with enhanced expression of CD4 -???CD4hi??? effectors. Autoimmune diabetes-prone NOD mice display a unique set of antigen-experienced ???CD4lo??? T cells that persist after primary stimulation. Here, we report that a population of ...
Nevertheless, little is known about the reemerging B cells. We analyzed dynamic changes in the repopulating B cells, particularly the postswitch B cells, and studied the mutational patterns of Ig genes in antigen-experienced B cells.MethodsFive patients with active rheumatoid arthritis (RA) were ...
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to en...
Antigen-experienced cells (CD4+/8+CD45RO+) were further assessed as TCM (CD62L+CCR+/− or TEM (CD62L-CCR7-. (Antigen-inexperienced cells (CD45RO−) were further interrogated for TEFF (CD62L−CCR7−) and TSCM (CD62L+CCR7+CD95+CD127+) status. Where > 10% of events fell ...
Mature antigen‐experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint[J] . AntonioManzo,BarbaraVitolo,FrancesHumby,RobertoCaporali,DavidJarrossay,FrancescoDell... A Manzo,B Vitolo,F Humby,... - 《Arthritis & Rheuma...
cific CD8+ T cells. Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Egui, AdrianaCarmen Thomas, MCarrilero, Bartolomé...
BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity matura...
BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen- experienced B cells. Semin. Immunol. 18: 297-304... Laura,S.,Treml,... - 《Seminars in Immunology》 被引量: 73发表: 2006年来源期刊 Seminars in Immunology 研究点推荐 B cells B lymphocyte 引用...