Anticancer drugsAnticancer targetsNatural productsCytotoxic compoundsMechanism of actionNatural products are recognized as a rich source of bioactive compounds for modern medicine, particularly those for the treatment of cancer. Since natural products are metabolites of living organisms, they have a tendency...
Some other essential metals have been studied and proposed as metallodrugs. Regarding the mechanism of action, at first, interaction with DNA was thoroughly studied and research leads to the proposal of adducts formation by direct bond between platinum and DNA bases mainly. Later on, cell death ...
► Investigation of the anticancer activity of two small β2,2-amino acid derivatives ► Elucidation of the mechanism of action to explore drug potential ► Induction of necrosis and apoptosis via the mitochondria mediated pathway ► Similar cancer cell killing properties as reported for larger...
Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. This review summarizes the studies conducted in our laboratory on the mechanisms of thyroid hormone action over the past two decades. We have attempted to ... RCJ Ribeiro,JW Apriletti,RL Wagner,......
Given the important role of this mechanism in cancer progression, in the following section, we have described the effect of ALT on each of the mentioned mechanisms in further detail. 5. The effect of ALT on cancer cell apoptosis Apoptosis is programmed cell death that is involved in survival/...
This review focuses on important and emerging aspects of this field, highlighting breakthroughs in unresolved questions as well as novel techniques and approaches that have been taken in recent studies. We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with ...
Carbonic Anhydrase Inhibitors: Possible Anticancer Drugs With a Novel Mechanism of Action. Drug Development Research. 2008; 69: 297-303. http://dx.doi.org/10.1002/ddr.20262Supuran CT.Carbonic anhydrase inhibitors:possible anticancer drugs with a novel mechanism of action. Durg Dev. Res . 2008...
Further, many of them have been successfully proved for their chemopreventive property by inducing apoptosis equivalent to certain other chemical drugs without causing any side effects. The combinational role of herbal and dietary phytochemicals has proved to be very effective against cancer prevention. ...
Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S (2007) Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off- target" effect? Mini-Rev Med Chem 7:1035-1039Havelka AM,Berndtsson M,Olofsson MH, et al.Mechanisms of action...
Berners-Price S J,Ronconi L,Sadle r P J.Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy . 2006Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy....