How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain MetastasesInt J Mol Scidoi:10.3390/ijms21010022AngeliNguyenJaninBousquet
CPTs are anticancer drugs isolated from the bark and stem of Camptotheca acuminata, a tree native to China used in traditional Chinese medicine. They selectively inhibit the nuclear enzyme DNAtopoisomerase, type I and possess antitumor activity. They are potent topoisomerase inhibitors that interfere wi...
the synthesis of the sugar chain that serves as an alarm signal—but do not trap PARP on DNA with the same strength. The team observed that both inhibitors kill cancer cells with the same efficiency, but that the inhibitor that weakly binds PARP to DNA is much less ...
Impact of Benzimidazole Containing Scaffolds as Anticancer Agents through Diverse Modes of Action Conclusion: The focus of this review is on recent advances in drug design and development, as well as benzimidazole derivatives and how they work on ... S Sharma,M Gupta,GJ Sahu - 《Current Bioactiv...
How to improve the selectivity of anticancer drugs on tumor cells, lowering the low toxicity and side effects is particularly important to improve the solubility of hardly contain anticancer drugs. 翻译结果2复制译文编辑译文朗读译文返回顶部 what should we do to improve anti-tumor drugs on tumor cell...
However, in vivo drug concentration in the plasma often needs to be achieved at μmol/L for adequate efficacy, especially for anticancer drugs. One would wonder why there is a large discrepancy between in vitro IC50 and in vivo EC50. One of the important factors may be due to the low ...
Zydelig (idelalisib) is not a chemotherapy drug, but a targeted anticancer treatment taken twice daily by mouth. Targeted drug therapies like Zydelig work by blocking specific pathways that allow the cancer to grow uncontrolled. Zydelig is used in combination with rituximab (Rituxan) to treat chroni...
Rakuten Medical is developing antibody conjugates based on the photoimmunotherapy platform as a new precision tumor-targeting anticancer approach that is being investigated for use as a single agent or in combination with Immuno-oncology modulators to treat locoregional and dissemina...
Matter A. Glivec (ST571, imatinib), a rationally developed, targeted anticancer drug. Nature Rev. Drug. Discov. 1, 493–502 (2002). Article CAS Google Scholar Wacker, D. et al. Conserved binding mode of human β2 adrenergic receptor inverse agonists and antagonist revealed by X-ray ...
Opdivo(nivolumab) andYervoy(ipilimumab) are two anticancer medications. While they are both effective treatment options for many different types of cancer, research shows they work better when taken together for some types of cancer. What are Opdivo and Yervoy?