Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate.Conventional treatments for cancer therapy,such as chemotherapy,and radiotherapy,have been hampered by their side effects.Natural product-derived plants have been used for decades to treat diseases....
Regarding the mechanism of action, at first, interaction with DNA was thoroughly studied and research leads to the proposal of adducts formation by direct bond between platinum and DNA bases mainly. Later on, cell death by means of apoptosis was mentioned, and therefore, the formation of ...
Herein, we summarized the mechanism of kaempferol in the treatment of breast cancer. We found that kaempferol mainly produced anti breast cancer effects in three following ways:(1) inhibiting the growth of breast cancer cells; (2) inducing the apoptosis of breast cancer cells; (3) inhibiting mi...
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 2013 ; 39:74-88; PMID: 23890065 ; http://dx... M Ciampricotti,CS Hau,CW Doornebal,... - 《Nature Medicine》 被引量: 254发表: 2012年 Immunological Effects of Conventional Chemotherapy...
(PGBD5), DENN/MADD domain containing 2D (DENND2D) and formin-like 1(FMNL) have also been identified to be associated in SKOV-3 cell death induced by 17βH-neriifolin.These findings may provide new insights on the potential of 17βH-neriifolin's mechanism of action in killing ovarian ...
Houghton PJ, Sosinski J, Thakar JH, Houghton JA: Diarylsulonyluras: new anticancer agents with novel activities, toxicities and mechanism of action. Proc. Int. Congress on neoadjuvant chemotherapy. In: Banzet P, Holland JF, Kayat D, Weil M (eds) Neo-adjuvant Chemotherapy. Springer Verlag, ...
Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer Castrate-resistant prostate cancer (CRPC) is a disease where survival is poor and treatment is challenging. Over the past 3 years, significant advances in ... R Pili,O Al-Ustwani,N Gupta,... - 《...
structure elucidationX-ray crystallographyLaulimalide and peloruside A are microtubule-stabilizing agents (MSAs), the mechanism of action on microtubules of ... AE Prota,K Bargsten,PT Northcote,... - 《Angewandte Chemie International Edition》 被引量: 96发表: 2014年 Mechanistic crystallography....
Mechanism of action and resistance to monoclonal antibody therapy. Seminars Oncol. 30, 424–433 (2003). CAS Google Scholar Berns, K. et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12, 395–402 (...
The particularly offensive, and often even life-threatening and difficult to restrain side effects, significantly degrade the quality of life of patients and are often responsible for the cessation of therapy. This is the result of a non-specific mechanism of action and the low selectivity of ...