The mechanism of disease, as well as the mechanism of action (MOA) for any particular drug, is the primary goal of scientific publications, and a secondary goal of medical publications and regulatory submissions. The chapters in this book on MOA disclose the role of MOA in regulatory ...
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion Nat Med, 8 (2002), pp. 1039-1800 doi:10.1038/nm0902-1039c View in ScopusGoogle Scholar 38. E.J. Wherry T cell exhaustion Nat Immunol, 12 (2011), pp. 492-499 doi:10.1038/ni.2035 CrossrefView ...
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limit...
this review, we emphasize the miRNAs that are involved in the regulation of drug resistance among different cancers and probe the mechanisms of the deregulated expression of miRNAs. The molecular targets of miRNAs and their underlying signaling pathways are also explored comprehensively. A holistic unde...
In this study, we investigated the mechanism of action of the third-generation benzopyran compounds, TRX-E-002-1 and TRX-E-009-1. High-content screening of a panel of 240 cancer cell lines treated with TRX-E-009-1 demonstrated it has broad anti-cancer potential. Within this screen, ...
If an NK cell expressing PD-L1 is treated with a PD-L1 antibody, the interaction activates PD-L1+ NK cells to control the growth of tumors by killing those tumors and by the secretion of cytokines. This demonstrates a novel mechanism of action that provides a significant role for the NK ...
As hypothesized based on their mechanism of action, combination of PD-1 and CTLA-4 blockers has been successful in increasing the response rates and median survival time in cancer patients. Nivolumab plus ipilimumab combination has been approved for 3 indications including, metastatic melanoma, advanc...
Herein, we summarized the mechanism of kaempferol in the treatment of breast cancer. We found that kaempferol mainly produced anti breast cancer effects in three following ways:(1) inhibiting the growth of breast cancer cells; (2) inducing the apoptosis of breast cancer cells; (3) inhibiting mi...
In summary, bortezomib-mediated proteasome inhibition sensitises previously resistant HPV-positive HNSCC cells to TRAIL-induced cell death through a mechanism involving both the extrinsic and intrinsic pathways of apoptosis. The cooperative effect of these two targeted anticancer agents therefore represents ...