Antibody modification and conjugation. In: Bioconjugate Techniques. Academic Press, San Diego, pp. 456e493.Hermanson, G. T. (1996) Antibody Modification and Conjugation: Bioconju- gate Techniques, pp. 478 - 483, Academic Press Inc., San Diego, CA...
Antibody modification and conjugation. Bioconjugate Techniques. Oxford, United Kingdom: Academic Press; 2008: 783- 823.Hermanson GT (2013) Chapter 20: antibody modification and con- jugation. In: Hermanson GT (ed) Bioconjugate techniques, 3rd edn. Academic Press, Boston, pp 867-920...
Hermanson GT (1996) Antibody modification and conjugation In: Hermanson GT, editor. Bioconjugate Techniques . San Diego, USA: Academic Press; pp. 456–493.Hermanson GT. Antibody modification and conjugation: bioconjugate tech- niques. San... GT Hermanson 被引量: 49发表: 2008年 Antibody Modificat...
Site-selective modification strategies in antibody-drug conjugates. Chem Soc Rev. 2021;50:1305–53. https://doi.org/10.1039/D0CS00310G. Article CAS PubMed Google Scholar García-Vilas JA, Medina MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its ...
Another conjugation platform was also reported by using sortase A-mediated transpeptidation reaction, generating ADCs with cytotoxins coupled to pre-defined sites [51]. This method includes C-terminal modification of antibody heavy and light chains with sortase A recognition motif, LPETG, which make...
conjugation. At present, formyl glycine-generating enzyme (FGE) and transglutaminase (TG) are commonly used.112However, it is worth noting that the immunogenicity may be induced upon modification of the amino acid sequences. Site‐specific ADCs can also be generated from glycan remodeling and glyco...
In this Review, we discuss strategies to select the best target antigens as well as suitable cytotoxic drugs; the design of optimized linkers; the discovery of bioorthogonal conjugation chemistries; and toxicity issues. The selection and engineering of antibodies for site-specific drug conjugation, ...
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP...
The conjugation of antibodies to a macrocyclic conjugate compound wherein the conjugate compound has the structure (I), wherein R. sup.1 is - -(CH.sub.2).sub.p --R.sup.6 --CH.sub.2).sub.q -- where p and q are the same or different and ar... D Parker,TA Millican - US 被...
Pfizer has initiated additionalclinical trialsthat showed the benefit ofMylotarg for patients with early diagnosis of the disease, and subsequent modification of the dosage suggests a comeback for this drug. Until recently, the reasons for the few successes were due to the high complexity, co...