a, Schematic diagram of antibody (Ab) diffusion to reach the deep tissue antigen (Ag) target. Ka(T) is the association constant of the Ab–Ag binding reactions at a given temperature T, and Deff is the effective diffusion coefficient of free Ab as a function of the antibody spatial locati...
First,ASCsare professionalsecretory cellswhose biology evolved to optimize the large-scale synthesis, folding, assembly, and secretion of immunoglobulins (Ig). It is thus not surprising that many great contributions in the field ofcell biologyhave come from the study of ASCs, such as the identifi...
aThe schematic diagram of several SARS-CoV-2 BA.2-related subvariants evolution. Some additional mutations in the spike acquired by XBB.1.5, EG.5.1, HK.3, BA.2.86, and JN.1 were displayed.bThe relative frequencies of BA.2.86 and JN.1* over time. The data to produce the chart were c...
The sections on slides were imaged at 20X using a Leica 5000B microscope, and images were captured with Stereo Investigator (Version 2023.2.2). Regions of interest included the neocortex (at the level of pallidum), midbrain (level of superior colliculi), and brainstem (mesencephalic trigeminal n...
(B) Schematic diagram of ALiCE, which is composed of two identical LCs (ACE-LC) and two different HCs (ACE–HC–VL and ACE–HC–VH). (C) Expression of ACE–HC–VH, ACE–HC–VL and ACE-LC chains in FreeStyle 293-F cells. Proteins in cell supernatants were resolved by SDS-PAGE ...
Consort flow diagram. Seventeen patients did not meet the inclusion criteria at screening and accordingly were not enrolled in the trial. Three patients underwent screening procedures twice prior to enrollment. 31 enrolled patients received FLYSYN at the indicated dose level of the assigned cohort. Sa...
[Schematic diagram of Huisgen 1,3-dipolar cycloaddition](2) Diels-Alder reaction, for example cycloaddition (for example, strain-promoted cycloaddition (SPAAC)) including a normal electron-demand Diels-Alder reaction and an inverse electron-demand Diels-Alder reaction, but the present invention is ...
SpyVLP for antibody responses that target multiple RBD epitopes using a competition ELISA against four different mAbs: FI-3A, FD-11A, EY6A and S309, that target three non-overlapping epitopes on the RBD with FD-11A and S309 showing overlap as defined by competition ELISA (see diagram in ...
Schematic diagram display the scope we get the image in the microscope. (j) One-way ANOVA with least significance difference (LSD) test was used to determine statistical significance of MBP. The mean OD value was decline in the EAE mice and after LINGO-1 treatment, it was increased. n(...
A, schematic diagram of the one-arm single chain Fab bispecific antibody XGFR, the XGFR2 antibody with C-terminal attachment of disulfide-stabilized scFvs, and the dual V domain (DVD) antibody XGFR-DVD. All VH and VL domains in the bispecific antibodies are derived from the parental antibo...