Finally, we studied examples of complexes containing IDPs/IDRs that adopt a stable structure upon binding. IDRs often bind through short linear motifs (SLiMs), recognizing folded domains driven by a few residues. The longer IDRs can contain arrays of SLiMs and can also form stable structures upo...
Drug development based on target proteins has been a successful approach in recent decades. However, the conventional structure-based drug design (SBDD) pipeline is a complex, human-engineered process with multiple independently optimized steps. Here, we
Yet, considering a wider range of immunological proteins/traits may provide greater insights into system-level immunological changes, elucidate potential common/specific immune-related pathophysiologic mechanisms, and identify novel treatment targets. We conducted two-sample MR analyses to test whether a ...
Merck KGaA, Darmstadt, Germany, will leverage Biolojic Design’s AI capabilities to create potential best-in-class multi-specific antibodies that uniquely modulate biology Collaboration designed to deliver immunology and oncology programs, including anti...
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In a recent study by Radtke et al., a multi-omics spatial biology approach helps shed light on early relapsing lymphoma patients
近日,恒瑞医药自主研发的Nectin-4抗体偶联药物(antibody-drug-conjugate, ADC)注射用SHR-A2102获得美国食品和药物监督管理局(FDA)授予快速通道资格(fast track designation, FTD),用于治疗晚期尿路上皮癌,获得这一资格将有利于加快推进临床...
Another early assay for TK activity was also a radiometric enzyme activity assay. This assay employed the use of the thymidine analog [125I]-5-iodo-2-deoxyuridine (IUdR) as a substrate and was named the TK-radio enzymatic assay (TK-REA) [112]. The level of phosphorylated IUdR was quant...
et al. Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc. Natl. Acad. Sci. USA 105, 17736–17741 (2008). Article CAS PubMed PubMed Central Google Scholar Ekiert, D.C. et al. Antibody recognition of a highly conserved influenza virus epitope. ...
(e.g., NDG, NAG, BMA) in the crystal structure were removed. Missing loops and hydrogen atoms were added to the cleaned structure of the antibody/antigen complex, which was then subjected to initial refinement using the Relax application in Rosetta. The relaxed structure with the lowest ...