THE STRUCTURE OF AN ANTIBODY COMBINING SITEdoi:10.1016/B978-0-12-043950-8.50036-XSteven K. DowerRaymond A. DwekBiomolecular Structure and Function
The crystal structure of the complex of the anti-lysozyme HyHEL-10 Fab and hen egg white lysozyme has been determined to a nominal resolution of 3.0 A. The... DR Davies,S Sheriff,EA Padlan - 《Journal of Biological Chemistry》 被引量: 1531发表: 1988年 Structure of an antibody-lysozyme...
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex The crystal structure of the complex of the anti-lysozyme HyHEL-10 Fab and hen egg white lysozyme has been determined to a nominal resolution of 3.0 angstr... EA Padlan,EW Silverton,S Sheriff,...
The formation of the isoaspartate (isoAsp) is one of spontaneous degradation processes of proteins, affecting their stability and activity. Here, we report for the first time the crystal structures of an antibody Fab that contains isoAsp in the complemen
The basic antibody structure is a Y-shaped protein molecule featuring two heavy and two light polypeptide chains. One can visualize the Y antibody structure broken down as a V standing on a lowercase L with a line on either outside edge of and parallel to the V. The lowercase L, known ...
Evidently, such receptor-mimicking antibodies constitute interesting templates to approach the structure of a ligand binding site on its receptor. The goal of this study was, therefore, to elucidate the functional architecture of the paratope of Mα2-3, an antibody that shares a number of ...
the cleavage of the drug, and (iv) the self-immolative spacer Future directions in the field are proposed. that liberates the drug. The final piece is the cytotoxic drug. Many payloads have been attached to an antibody, includ- Key words: antibody-drug conjugate, cytotoxic payload, ...
Monoclonal antibodies body, which a structure, which the human - interleukin - 2 (tcgf) and the light chain (lambda) of human immunoglobulin, and - - hybri... Monoclonal antibodies body, which a structure, which the human - interleukin - 2 (tcgf) and the light chain (lambda) of human...
We determined the sequence, specificity for structurally related cardenolides,and three-dimensional structure of the anti-digoxin antibody 40–50 Fab in complex with ouabain. The 40–50 antibody does not share close sequence homology with other high-affinity anti-digoxin antibodies. Measurement of the...
Fibriansah, G. et al. DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.Science349, 88–91 (2015) ArticleCASADSGoogle Scholar Kostyuchenko, V. A., Zhang, Q., Tan, J. L., Ng, T. S. & Lok, S. M. Immature and ...