THE STRUCTURE OF AN ANTIBODY COMBINING SITEdoi:10.1016/B978-0-12-043950-8.50036-XSteven K. DowerRaymond A. DwekBiomolecular Structure and Function
Describe the structure of an antibody. 05:37 Distinguish between the following : (Give at least one point of dist... 02:18 Distinguish between the following : (Give at least one point of dist... 03:35 Distinguish between the following : (Give at least one point of dist... Text Soluti...
Structure of an antibody-lysozyme complex unexpected effect of conservative mutation. The structure of the complex between the Fab HyHEL-5 and chicken lysozyme revealed a large interface region containing 23 lysozyme and 28 Fab residues. Arg... S Chacko,E Silverton,L Kam-Morgan,... - 《Journa...
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Evidently, such receptor-mimicking antibodies constitute interesting templates to approach the structure of a ligand binding site on its receptor. The goal of this study was, therefore, to elucidate the functional architecture of the paratope of Mα2-3, an antibody that shares a number of ...
Monoclonal antibodies body, which a structure, which the human - interleukin - 2 (tcgf) and the light chain (lambda) of human immunoglobulin, and - - hybri... Monoclonal antibodies body, which a structure, which the human - interleukin - 2 (tcgf) and the light chain (lambda) of human...
et al. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886–1889 (2002). CAS PubMed Google Scholar Buckley, D. L. et al. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1alpha. Angew. Chem. Int. Ed. Engl...
We determined the sequence, specificity for structurally related cardenolides,and three-dimensional structure of the anti-digoxin antibody 40–50 Fab in complex with ouabain. The 40–50 antibody does not share close sequence homology with other high-affinity anti-digoxin antibodies. Measurement of the...
et al. Design of coltuximab ravtansine, a CD19-targeting antibody–drug conjugate (ADC) for the treatment of B-cell malignancies: structure–activity relationships and preclinical evaluation. Mol. Pharm. 12, 1703–1716 (2015). Article CAS PubMed Google Scholar Damelin, M. et al. Anti-EF...
A Nanobody-Stabilized Active-State KOP Structure We adopted nanobody technology to obtain an active-state-like crystal structure of KOP, since structure determination of signaling complexes remains incredibly challenging. Nb—small single-chain antibodies—have facilitated the structural characterization of ...