Fig. 1: Principle and performance of dynamic mass photometry. a, Schematic diagram of dynamic mass photometry of protein complexes diffusing on an SLB. The images were acquired at 331 Hz and processed with a sliding median filter, which showed individual protein complexes on the bilayer as dif...
A central effort of today’s neuroscience is to study the brain’s ’wiring diagram’. The nervous system is believed to be a network of neurons interacting with each other through synaptic connection between axons and dendrites, therefore the neuronal connectivity map not only depicts the underlyi...
To further demonstrate that the increased cleavage is because of a direct cleavage by BACE1 and not merely because of secondary effects, the epitope-tagged proteins were immunoprecipitated from the cell lysates using an antibody against the HA-tag and subject to an in vitro cleavage assay by purif...
Schematic diagram of the mechanisms by which TGF-β1 attenuates rosiglitazone-induced adipogenic differentiation in OP9-DL1 cells. TGF-β1 increases the recruitment of Smad2/3 and HDAC1 and reduces the level of H3K14ac at the promoter region of the PPARγ gene, thereby transcriptionally down-reg...
CAR-T cells with the function of cell-free virus clearance, we constructed 10E8scFv-Fc, an Fc-fusion version of 10E8, which is a broad and potent bNAb whose binding site does not overlap with the CAR molecule, by ligating 10E8 to a mutant of IgG1 Fc capable of mediating antibody-...
Also, according to this method, a secondary antibody encoded with a fluorescent material generally needs to be used, and thus, analysis may become complicated and related costs tend to increase. As illustrated in FIG. 11, in the optic fiber microbead array, microbeads are encoded with a ...
structure, where they are specialized into subclasses or grouped into superclasses. These classification problems are known in the machine learning (ML) literature as hierarchical classification (HC), since instances are assigned to classes associated with nodes of a hierarchy. Depending on the domain...
The structure of this sensor allows for optical and capacitance measurements to be taken simultaneously in real-time. Red = cell cytoplasm; blue = cell nucleus; green = NPs; sky blue = electric circuit of the cell and capacitance sensor. schematic diagram is...
On one hand, protein recognition elements (antibody, lectin and receptor protein) and DNA aptamer, are complicated in preparation and purifica- tion, and lack the stability under a variety of monitoring conditions or long-term storage27. On the other hand, although carbohydrate exhibits the merits...
FIG. 15 is a cross-sectional diagram of an inorganic DFB laser sensor chip described below as Example 7. FIGS. 16A-16D are perspective views, partially in cross-section, of different types of one dimensional gratings which can used for the DFB laser sensor. ...