The Ab lock significantly inhibited the IL-1β-binding by 68-fold compared with Canakinumab, and MMP-9 completely restored the IL-1β neutralizing ability of pro-Canakinumab within 60 min and blocked IL-1β-downstream signaling and IL-1β-regulated genes (i.e., IL-6). It is expected ...
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Spatial tolerance refers to the favourability of bivalent antibody binding according to the spatial distribution of the two adjoining antigens. Some antibodies stretch and compress more than others, leading to a greater chance of entering and remaining in a bivalent state. In our model, we propose...
Brief digestion of an Ig protein with the protease papain results in two identical Fab fragments, so called because they retain the antibody’s antigen-binding ability (Fig. 4-2). The remaining fragment of the Ig protein is called the Fc region because it crystallizes at low temperat...
This ability of animal immune systems to produce antibodies capable of binding specifically to antigens can be harnessed to manufacture probes for detection of molecules of interest in a variety of research and diagnostic applicat...
This flexibility of formats allows several advantages including the ability to easily change the fluorescent dye used, without impacting the degree of labeling of the same antibody and the ability to prepare a large batch of modified antibody and label only a small amount as needed, again, preserv...
experiment using immune and naïve libraries resulted in more unique clones with better binding from the immune library, suggesting the ability of immune libraries to better generate mAbs against targets of a specific infection [83]. Currently, raxibacumab, a naïve antibody library-derived mAb ...
Origin of the Ab response to the PC determinant of Proteus morganii (PC-PM) was explored, where a single somatic mutation in CDR2 of V$\\sb{m H}$ confers significant Ag-binding ability. As opposed to the undetectable ELISA binding of Ab with unmutated CDR2, the mIg equivalent on B ...
Anti-spermatozoa antibodies exert heterogeneous effects on the ability of spermatozoa to fertilize. The inhibiting effect of anti-spermatozoa antibodies on the motility of spermatozoa by binding to their surface and by agglutinating processes is well-known (Zouari R et al: Fertil Steril (1993) 59, ...
Immunogenicity is the ability of a molecule to solicit an immune response. There are three characteristics that a substance must have to be immunogenic: foreignness, high molecular weight and chemical complexity. Foreignness is required so that t...