Here, we show that neutralization level is highly predictive of immune protection, and provide an evidence-based model of SARS-CoV-2 immune protection that will assist in developing vaccine strategies to control the future trajectory of the pandemic....
Our understanding of antibody structure has grown progressively more refined with advances in protein chemistry, molecular biology, and cellular immunology. The complexities of antibodies have been deciphered by applying a reductionist approach through which the immunoglobulin structure is simplified in stages...
the IC50values of DNA damaging agents are able to reach picomolar level, thus ADCs conjugated with DNA damaging agents are sometimes more effective and may work independent to cell cycles (compared to tubulin inhibitors that work mainly on the mitocytosis phase), and they may...
By applying molecular biology methods, it was possible to show that viral DNA and viral mRNA was demonstrated against IE and L antigens in 90% of the vascular walls of atheromatous subjects and in 50% of the vascular walls of atheromatous subjects, indicating the role of the virus in the ...
New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133). Cells Tissues Organs. 2008;188(1–2):127–38. https://doi.org/10.1159/000112847. Article CAS PubMed Google Scholar Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H. ...
While strategies such as chemotherapy and immunotherapy have become the first-line standard therapies for patients with advanced or metastatic cancer, acquired resistance is still inevitable in most cases. The introduction of antibody‒drug conjugates
formats) include: immunoprecipitation1,3, in vivo and in vitro cell depletion2,10,15, inhibition of CD8 T cell proliferation3, blocking of cytotoxicity3,4, immunohistochemical staining5,6 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and spatial biology (IBEX)29,30....
- 《Journal of Molecular Biology》 被引量: 2262发表: 1987年 Design of a Novel Globular Protein Fold with Atomic-Level Accuracy A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a g... B ...
The adaptive immune response to influenza virus infection is multifaceted and complex, involving antibody and cellular responses at both systemic and mucosal levels. Immune responses to natural infection with influenza virus in humans are relatively broa
Peter DSenter, inCurrent Opinion in Chemical Biology, 2009 In vitroandin vivoeffects ofMMAEADCs. (a) CD30+ Karpas 299 cells were exposed to cAC10-Val-Cit-MMAE or the non-binding Rituxan-Val-Cit-MMAE ADCs, and the cytotoxic effects were measured after 96hours [44]. (b) Therapeutic...