conformational changemacrolide antibiotic binding protein (MABP)non-canonical ABC transporterMacrolide antibioticErythromycinRv3197 (MABP-1), a non-canonical ABC protein in Mycobacterium tuberculosis, has ATPase activity and confers inducible resistance to the macrolide family of antibiot...
AlbA has been reported as a binding protein conferring resistance against the potent antibiotic albicidin17,19,20. Previous studies already mentioned a single high-affinity binding site for albicidin in AlbAS20,34, and an α-helical structure19, but they lacked both the knowledge of the chemica...
The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus Paramecium bursaria Chlorella virus type 1 (PBCV-1) is a very large, icosahedral virus containing an internal membrane enclosed within a glycoprotein coat ... N Nandhagopal,AA Simpson,JR Gurnon,.....
Modelling dynamics in protein crystal structures by ensemble refinement It has been clear since the early days of structural biology in the late 1950s that proteins and other biomolecules are continually changing shape, and that these changes have an important influence on both the structure and func...
To evaluate the toxicity of chloramphenicol (CAP) at the protein level, the interaction between CAP and human serum albumin (HSA) was investigated by fluorescence, Ultraviolet-visible (UV-Vis) absorption, Fourier transform infrared (FT-IR) spectroscopy and molecular docking methods. Fluorescence data...
Aurodox is a member of the family of kirromycin antibiotics, which inhibit protein biosynthesis by binding to elongation factor Tu (EF-Tu). We have determined the crystal structure of the 1:1:1 complex of Thermus thermophilus EF-Tu with GDP and aurodox to 2.0-Å resolution. During its ...
BCA reagent kit for protein estimation was obtained from Pierce (Rockford, IL, USA). All other chemicals Results We monitored the ability of nystatin to affect the ligand binding of 5-HT1A receptors in native hippocampal membranes. As mentioned earlier, nystatin specifically interacts with ...
S-1006 exhibited high affinity for the penicillin-binding protein (PBP)-3 of Escherichia coil K12 as well as affinity for PBP-1a, -1bs and-2. In the case of affinity for the PBPs of Staphylococcus aureus ATCC 25923, S-1006 showed IC50 values of less than 0.2μg/ml for PBPs-1, -...
The role of glycosylation in protein antigenic properties Glycosylation of proteins is a common event and contributes to protein antigenic properties. Most data have been obtained from model studies on glycoproten... E Lisowska - 《Cellular & Molecular Life Sciences Cmls》 被引量: 133发表: 2002年...
Protein-ligand interaction Spectroscopy Thermodynamics Molecular Docking Molecular Dynamics Introduction Proteins are the chief actors within the cell that allows multiple tasks in their ability to bind with small molecules. They are the major destinations for all medicines in organisms. The interaction stud...