The drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca. Here we show that AlbA binds albicidin with low nanomolar affinity resulting in full inhibition of its antibacterial activity. We report on the crystal structure of the drug-binding domain of AlbA (AlbAS) in ...
Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations The understanding of protein—ligand binding is of critical importance for biomedical research, yet the process itself has been very difficult to study bec... I Buch,T Giorgino,GD Fabritiis - 《...
The yfdX family proteins are known for long time to occur in various virulent bacteria including their multidrug resistant (MDR) strains, without any direct assigned function for them. However, yfdX protein along with other proteins involved in acid tole
产品描述 Clindamycin is a broad spectrum antibiotic targeting primarily gram positive and gram negative bacteria such as Clostridium and Bacteroides species. It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit and interfering with tRNA activity during translation. ...
protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA ...
ß-Lactam Antibiotic-Induced Release of Free Endotoxin: In Vitro Comparison of Penicillin-Binding Protein (PBP) 2-Specific Imipenem and PBP 3-Specific Ce... The relative effects of two β-lactam antibiotics, penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime, ...
产品描述 Clindamycin is a broad spectrum antibiotic targeting primarily gram positive and gram negative bacteria such as Clostridium and Bacteroides species. It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit and interfering with tRNA activity during translation. ...