Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target MYCOBACTERIUM肺结核抗菌素蛋白质抗药绑定世界范围抢救治疗摘要:Qingqing ZhangCollege of Life SciencesKaixia MiTianjin International Joint Academy of Biotechnology & MedicineZihe Rao...
In this work, we characterized the MerR-like drug-binding protein AlbA that displays a high binding affinity to albicidin. We elucidated the crystal structure of the complex between albicidin and the drug-binding domain AlbAS, demonstrating that this domain is structurally distinct from other dru...
Members of the ATP-binding cassette (ABC)-F protein subfamily collectively mediate resistance to a broader range of clinically important antibiotic classes than any other group of resistance proteins and are widespread in pathogenic bacteria. Following over 25 years' of controversy regarding the mechanis...
Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation. Mol. Microbiol. 59, 265–275 (2006). Article CAS PubMed Google Scholar Waller, J. C. et al. A role for tetrahydrofolates in the metabolism of iron-sulfur...
Dynamics of protein ligand binding on multiple time scales: NADH binding to lactate dehydrogenase. Although the importance of atomic motion to how proteins function has been conjectured for several decades, the characterization of protein dynamics on mul... D Hong,N Zhadin,R Callender - 《Biochemi...
Macrolides (inhibit protein synthesis) azithromycin Zithromax infections of the respiratory tract and skin; STDs; otitis media; chronic obstructive pulmonary disease; pneumonia clarithromycin Biaxin infections of the respiratory tract and skin; otitis media erythromycin E.E.S., E-Mycin, Eryc infecti...
"Our technique with this new antibiotic approach is different -- instead of binding to the surface of the protein, we disrupt the structure of the protein, which stops it functioning." In one test Zhou said, the team saw a 500-fold resistance develop to a commonly used antibiotic over 30...
An example of this is observed in the evasion of the effects of MLSB (macrolides, lincosamide and streptogramin B) antimicrobial drugs by pathogenic strains of Streptococcus species, which prevents these drugs from binding to its 50 S ribosomal subunit to block biosynthesis of protein by post-...
All previously published structures that were used in this work for model building and structural comparisons were retrieved from the RCSB Protein Data Bank under accession codes 6XHW51, 4V7V30 and 1YJN48. Source data are provided with this paper. References Antibiotic Resistance Threats in the ...
The C-terminal domain of the nucleotide-binding domain protein Wzt determines substrate specificity in the ATP-binding cassette transporter for the lipopolysaccharide O-antigens in Escherichia coli serotypes O8 and O9a. J. Biol. Chem. 280, 30310–30319 (2005). CAS PubMed Google Scholar Panta...