Some of these shortcomings could be alleviated by returning to the concept, originally put forward by Singh and Vaughan Williams, of classes of drug action rather than classes of drug per se. This approach would be pharmacologically more realistic than trying to assign each antiarrhythmic agent to...
Antiarrhythmic drugs comprise many drug classes and have several mechanisms of action. Some classes and even some specific drugs within a class are effective with only certain types of arrhythmias. Therefore, attempts have been made to classify the different antiarrhythmic drugs by mechanism. Although ...
Quick Links: Clinical Disorders Therapeutic Classes Mechanism Classes Guided Learning - Antiarrhythmic Drugs(NOTE: Turn off or override browser pop-up blockers.) Underlying Mechanisms of Drug Action How does changing the slope of phase 4 of sinoatrial node action potentials affect heart rate? click...
Drug Therapeutic Uses Comments amiodarone ventricular tachycardia, including ventricular fibrillation; atrial fibrillation and flutter (off-label use) very long half-life (25-60 days); Class I, II, III & IV actions and therefore decreases phase 4 slope and conduction velocity; side effects include ...
Many different classes of antiarrhythmic drugs have been used for rhythm control, with inconsistent results and adverse effects on mortality and morbidity. Of the available antiarrhythmic drugs, amiodarone is the single most effective drug in the prevention of atrial fibrillation recurrences and ...
Amiodarone, originally developed over 20 years ago, is a potent antiarrhythmic drug with the actions of all antiarrhythmic drug classes. It has been succes... JW Gill,RC Heel,A Fitton - 《Drugs》 被引量: 441发表: 1992年 Pharmacokinetics of amiodarone after intravenous and oral administration Se...
Intravenous lidocaine is a first-line drug in the treatment of VT. It should be administered as i.v. bolus doses of 0.5 mg/kg every 5 minutes, up to a total dose of 4 mg/kg, although it should be used with caution above cumulative doses of 2 mg/kg in conscious horses because the...
drug, which is usually its major action, is enclosed in a box. In the discussion of individual agents that follows, reference should also be made toTable 19-2for the electrophysiologic actions of representative antiarrhythmic drugs. The net effects of the relevantdrug classes and various action ...
Therapeutic drug monitoring: antiarrhythmic drugs. Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of... TJ Campbell,KM Williams - 《British Journal of Clinical Pharmacology》 被引量: 238发表: 2001年...
At higher rates of cell depolarizations, the relative time the channels spend in a rested (closed) state is reduced; therefore, there is a higher probability that the drug will bind to the activated and inactivated states at higher heart rates. In contrast, Class IB drugs bind primarily to ...