The drugs that comprise the different classes differ in their efficacy (and sometimes safety) for different arrhythmias. The following table summarizes drug classes and associated arrhythmias. This table only provides broad generalizations because the listed conditions are general descriptions and do not ...
The dosages for the most commonly used antiarrhythmic drugs are given in the table below. Classification and Dosing of Antiarrhythmic Drugs Empty CellDRUGDOG DOSECAT DOSE Class I IA Disopyramide 6–15 mg/kg PO q 8 hr Quinidine sulfate 5–10 mg/kg Quinidine gluconate 6–20 mg/kg PO...
Quinidine is the drug of choice for pharmacological conversion of atrial fibrillation. Quinidine sulfate is given via nasogastric tube at a dosage of 22 mg/kg every 2 hours until therapeutic concentrations are achieved (usually 4–5 doses) or signs of toxicity occur (see Table 7.1). If convers...
The following table summarizes Class III compounds in terms of their therapeutic use and some special or distinguishing characteristics. Drug Therapeutic Uses Comments amiodarone ventricular tachycardia, including ventricular fibrillation; atrial fibrillation and flutter (off-label use) very long half-life (...
Table 2. Definitions Vulnerable parameter. An electrophysiological parameter (e.g. diastolic depolarization, action potential duration, conduction velocity) involved in the genesis of arrhythmias and which should be modified by an antiarrhythmic drug through its action on channels or receptors (the target...
drug, which is usually its major action, is enclosed in a box. In the discussion of individual agents that follows, reference should also be made toTable 19-2for the electrophysiologic actions of representative antiarrhythmic drugs. The net effects of the relevantdrug classes and various action ...
--the change (+,-) in the rate of rise of phase 0 of the action potential from control value and the concentration of drug which caused the observed change NR--not reached NE--no effect The above data were recorded for a normal stimulated beat at a basic cycle length of 1000 ...
to in the literture as MJ 9067 (USAN and the USP Dictionary of Drug Names 1980, p. 122, United States Pharmacopeial Convention, Inc., 12601 Twinbrook Parkway, Rockville, MD 20852, Library of Congress Catalog Card No. 72-88571). Encainide has the following structural formula (1) ##STR1...
for the HPLC analyses are estimated to ensure that the drug peak and the plasma peaks do not have the same retention time. This is done by subsequent injections of the drug, plasma, and a co-injection with the drug and the plasma, followed by optimisation of the LC method parameters ...
(30 mg/kg, i.v.) and vagotomized at both sides under artificial respiration. A cannula for measuring blood pressure was inserted into the right femoral artery and a cannula for administering a drug was inserted into the right femoral vein. The standard lead II electrocardiogram and also the...