其三,III类抗心律失常药物(class III antiarrhythmic agents)=钾离子通道阻滞药(K+ channel blocker)=延长动作电位时程药: 一、这类药物的作用机制总说:这类药物有许多种类,其中有个别药物其实不仅仅只作用于钾离子通道,还可以作用于其他的离子通道。但是,如果我们仅把注意力放在药物对钾离子通道的作用上,则,其药理...
Class III (Vaughan-Williams classification) antiarrhythmic drugs prolong the cardiac action potential without affecting depolarisation. The 3 class III drugs currently in general use are amiodarone, Sotalol and bretylium. The presenting features of acute toxicity are different for each agent and are, ...
All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as “potassium channel...
Class III antiarrhythmic drugs are drugs which act as K+ channel antagonists and result in action potential prolongation without effect on the upstroke of the action potential.Antiarrhythmic Drugsdoi:10.1002/9780470692523.ch5Fogoros, Richard N
Class III antiarrhythmic action, e.g. the principle of delayed myocardial repolarization as an antiarrhythmic action, was described in 1970. This mode of action has become increasingly interesting with the increasing knowledge about mechanisms involved in initiation and perpetuation of cardiac arrhythmias ...
Class III antiarrhythmic agents are characterized by their ability to prol贸ong action potential and increase refractoriness. The use of these drugs, namely, sotalol hydrochloride and amiodarone hydrochloride, is rising. Both agents are effective for treating a range of ventricular arrhythmias, and ...
A variety of class III antiarrhythmic agents have been shown to block the delayed rectifier current, but their effects on other K + currents, particularly in human tissues, are less clear. We studied the concentration-dependent actions of the class III compounds d -sotalol, E-4031 and ambasil...
Cobbe SM.Class III antiarrhythmics:put to the SWORD-.Heart. 1996Cobbe SM. Class III antiarrhythmics: put to the SWORD? Heart. 1996; 75:111-113.Cobbe SM.Class III antiarrhythmics:put to the SWORD-. Heart . 1996COBBE S.M. Class III Antiarrhythmics: put to the SWORD. Heart. 1996; 75...
Current status of class III antiarrhythmic drug therapy.MAGNETIC RESONANCE IMAGINGAORTIC VALVE INCOMPETENCEREGURGITANT VOLUMECOLOR DOPPLER ECHOCARDIOGRAPHYStudies in animal models, as well as clinical experience with amiodarone and sotalol, suggest that action potential prolongation may be a useful ...
ANTIARRHYTHMIC CLASS III PROCESS Abstract of the Disclosure A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sit...