Classification of antiarrhythmic actions is reviewed in the context of the results of the Cardiac Arrhythmia Suppression Trials, CAST 1 and 2. Six criticisms of the classification recently published (The Sicilian Gambit) are discussed in detail. The alternative classification, when stripped of ...
ArticlePubMedCASGoogle Scholar Harrison DC. Antiarrhythmic drug Classification: new science and practical applications. American Journal of Cardiology 50: 185–187, 1985 ArticleGoogle Scholar Heger JJ, Nattel S, Rinkenberger RL, Zipes DP. Mexiletine therapy in 15 patients with drug-resistant ventricula...
Nattel S, Singh BN: Evolution, mechanisms, and classification of antiarrhythmic drugs: focus on Class III actions . Am J Cardiol 1999, 84 ( 9A ):11... J Wang,J Feng,S Nattel - 《Circulation》 被引量: 199发表: 1994年 The Sicilian Gambit ; A new approach to the classification of an...
Antiarrhythmic drugs act on the electrical conduction system of the heart. The most common use of these drugs is as part of a rhythm control strategy to maintainsinus rhythm. The Vaughan Williams classification system divides these agents based on their mechanisms of action at the cell membrane ―...
8.4Classification of Antiarrhythmic Drugs Most available antiarrhythmic drugs are potent compounds with a relatively narrowtherapeutic index. If these agents are used cautiously, they can play a key role in enhancing or prolonging the lives of patients; however, if they are misused (e.g., selection...
Arrhythmias refer to a deviation from normal heart rhythm. This includes atrial fibrillation, and many other phenomena. There are four classes of drugs that deal with such issues according to the Vaughan-Williams classification, let's learn about them now! 知识 科学科普 生物 健康 医学 ...
The Vaughan-Williams classification has severe limitations. When initially conceived, there were few antiarrhythmic drugs, and our understanding of their mechanisms was rudimentary. Now, with many more antiarrhythmic drugs, and with a much greater yet still incomplete understanding of drug mechanisms, thi...
Antiarrhythmic drugs.Antiarrhythmic drugs.Discusses several types of antiarrhythmic drugs. Classification of antiarrythmic agents; Mechanism of action; Clinical use; Pharmacokinetics; Adverse effects.HillisW.S.WhitingB.EBSCO_AspBritish Medical Journal (Clinical Research Edition)...
Fig. 1.Schematic representation of the electrophysiology of the cardiac action potential of myocardial tissue illustrating the 5 phases of the cardiac action potential and the Vaughan-Williams classification of antiarrhythmic therapies. Phase 4 represents spontaneous depolarization of pacemaker cells through ...
一、抗心律失常药物的作用机理(Action Mechanism of Antiarrhythmic Drugs) 324二、抗心律失常药的分类(Classification of …book.jd.com|基于6个网页 2. 作用机制 ...mic Drugs)270 一、抗心律失常药物的作用机制(Action Mechanism of Antiarrhythmic Drugs)270 二、抗心律失常药的分类(Cla…shop.cip.com.cn|基于...